1ziw

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(New page: 200px<br /> <applet load="1ziw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ziw, resolution 2.10Å" /> '''Human Toll-like Rec...)
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Revision as of 18:28, 12 November 2007

Image:1ziw.gif

Human Toll-like Receptor 3 extracellular domain structure

Overview

Toll-like receptors (TLRs) play key roles in activating immune responses, during infection. The human TLR3 ectodomain structure at 2.1 angstroms, reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich, repeats (LRRs). Asparagines conserved in the 24-residue LRR motif, contribute extensive hydrogen-bonding networks for solenoid stabilization., TLR3 is largely masked by carbohydrate, but one face is, glycosylation-free, which suggests its potential role in ligand binding, and oligomerization. Highly conserved surface residues and a TLR3-specific, LRR insertion form a homodimer interface in the crystal, whereas two, patches of positively charged residues and a second insertion would, provide an appropriate binding site for double-stranded RNA.

About this Structure

1ZIW is a Single protein structure of sequence from Homo sapiens with NDG, NAG, SO4 and GOL as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain., Choe J, Kelker MS, Wilson IA, Science. 2005 Jul 22;309(5734):581-5. Epub 2005 Jun 16. PMID:15961631

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