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1w77

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[[Image:1w77.gif|left|200px]]
[[Image:1w77.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1w77 |SIZE=350|CAPTION= <scene name='initialview01'>1w77</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1w77", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:C5p+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=C5P:CYTIDINE-5&#39;-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1w77| PDB=1w77 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w77 OCA], [http://www.ebi.ac.uk/pdbsum/1w77 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w77 RCSB]</span>
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}}
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'''2C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE (ISPD) FROM ARABIDOPSIS THALIANA'''
'''2C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE (ISPD) FROM ARABIDOPSIS THALIANA'''
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[[Category: Kaiser, J.]]
[[Category: Kaiser, J.]]
[[Category: Rohdich, F.]]
[[Category: Rohdich, F.]]
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[[Category: arabidopsis thaliana]]
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[[Category: Arabidopsis thaliana]]
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[[Category: cytidylyltransferase]]
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[[Category: Cytidylyltransferase]]
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[[Category: isoprenoid]]
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[[Category: Isoprenoid]]
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[[Category: non-mevalonate pathway]]
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[[Category: Non-mevalonate pathway]]
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[[Category: plantherbicide]]
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[[Category: Plantherbicide]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:15:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:32:12 2008''
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Revision as of 10:15, 3 May 2008

Image:1w77.gif

Template:STRUCTURE 1w77

2C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE (ISPD) FROM ARABIDOPSIS THALIANA


Overview

The homodimeric 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase contributes to the nonmevalonate pathway of isoprenoid biosynthesis. The crystal structure of the catalytic domain of the recombinant enzyme derived from the plant Arabidopsis thaliana has been solved by molecular replacement and refined to 2.0 A resolution. The structure contains cytidine monophosphate bound in the active site, a ligand that has been acquired from the bacterial expression system, and this observation suggests a mechanism for feedback regulation of enzyme activity. Comparisons with bacterial enzyme structures, in particular the enzyme from Escherichia coli, indicate that whilst individual subunits overlay well, the arrangement of subunits in each functional dimer is different. That distinct quaternary structures are available, in conjunction with the observation that the protein structure contains localized areas of disorder, suggests that conformational flexibility may contribute to the function of this enzyme.

About this Structure

1W77 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate., Gabrielsen M, Kaiser J, Rohdich F, Eisenreich W, Laupitz R, Bacher A, Bond CS, Hunter WN, FEBS J. 2006 Mar;273(5):1065-73. PMID:16478479 Page seeded by OCA on Sat May 3 13:15:08 2008

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