1w7g

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[[Image:1w7g.gif|left|200px]]
[[Image:1w7g.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1w7g |SIZE=350|CAPTION= <scene name='initialview01'>1w7g</scene>, resolution 1.65&Aring;
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The line below this paragraph, containing "STRUCTURE_1w7g", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Miu+Binding+Site+For+Chain+H'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MIU:N-{(1S)-1-{[4-(3-AMINOPROPYL)PIPERAZIN-1-YL]CARBONYL}-4-[(DIAMINOMETHYLENE)AMINO]BUTYL}-3-(TRIFLUOROMETHYL)BENZENESULFONAMIDE'>MIU</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1w7g| PDB=1w7g | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7g OCA], [http://www.ebi.ac.uk/pdbsum/1w7g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w7g RCSB]</span>
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}}
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'''ALPHA-THROMBIN COMPLEX WITH SULFATED HIRUDIN (RESIDUES 54-65) AND L-ARGININE TEMPLATE INHIBITOR CS107'''
'''ALPHA-THROMBIN COMPLEX WITH SULFATED HIRUDIN (RESIDUES 54-65) AND L-ARGININE TEMPLATE INHIBITOR CS107'''
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[[Category: Remiche, J.]]
[[Category: Remiche, J.]]
[[Category: Sauvage, E.]]
[[Category: Sauvage, E.]]
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[[Category: argatroban]]
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[[Category: Argatroban]]
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[[Category: coagulation]]
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[[Category: Coagulation]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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[[Category: thrombin]]
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[[Category: Thrombin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:15:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:32:17 2008''
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Revision as of 10:15, 3 May 2008

Image:1w7g.gif

Template:STRUCTURE 1w7g

ALPHA-THROMBIN COMPLEX WITH SULFATED HIRUDIN (RESIDUES 54-65) AND L-ARGININE TEMPLATE INHIBITOR CS107


Overview

Piperazinyl-amide derivatives of N-alpha-(3-trifluoromethyl-benzenesulfonyl)-L-arginine (1) were synthesized as graftable thrombin inhibitors. The possible disturbance of biological activity due to a variable spacer-arm fixed on the N-4 piperazinyl position was evaluated in vitro, against human alpha-thrombin, and in blood coagulation assay. Molecular modelling (in silico analysis) and X-ray diffraction studies of thrombin-inhibitor complexes were also performed. The fixation of bioactive molecules on poly(butylene terephthalate) (PBT) and poly(ethylene terephthalate) (PET) membranes was performed by wet chemistry treatment and evaluated by XPS analysis. Surface grafting of inhibitor 1d improved the membrane hemocompatibility by reducing blood clot formation on the modified surface.

About this Structure

1W7G is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design, synthesis and evaluation of graftable thrombin inhibitors for the preparation of blood-compatible polymer materials., Salvagnini C, Michaux C, Remiche J, Wouters J, Charlier P, Marchand-Brynaert J, Org Biomol Chem. 2005 Dec 7;3(23):4209-20. Epub 2005 Oct 19. PMID:16294249 Page seeded by OCA on Sat May 3 13:15:44 2008

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