8w23

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Current revision (16:09, 9 July 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8w23 is ON HOLD until Paper Publication
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==Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, TDI-2804 (consensus map).==
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<StructureSection load='8w23' size='340' side='right'caption='[[8w23]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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Authors: Malone, B.F., Zimmerman, J.L., Dow, L.E., Hite, R.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8w23]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W23 FirstGlance]. <br>
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Description: Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, TDI-2804 (consensus map).
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AE4:4-methoxy-~{N}-[4-oxidanylidene-2-[4-(2-oxidanylpropan-2-yl)phenyl]-1~{H}-quinazolin-7-yl]-6-phenyl-pyridine-3-carboxamide'>A1AE4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Hite, R.K]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w23 OCA], [https://pdbe.org/8w23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w23 RCSB], [https://www.ebi.ac.uk/pdbsum/8w23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w23 ProSAT]</span></td></tr>
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[[Category: Zimmerman, J.L]]
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</table>
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[[Category: Dow, L.E]]
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== Function ==
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[[Category: Malone, B.F]]
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[https://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Dow LE]]
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[[Category: Hite RK]]
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[[Category: Malone BF]]
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[[Category: Zimmerman JL]]

Current revision

Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, TDI-2804 (consensus map).

PDB ID 8w23

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