9cjy
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM structure of NC99 hemagglutinin trimer in complex with Fab BB798E 3-C07== | |
| - | + | <StructureSection load='9cjy' size='340' side='right'caption='[[9cjy]], [[Resolution|resolution]] 3.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9cjy]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus] and [https://en.wikipedia.org/wiki/Macaca_fascicularis Macaca fascicularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CJY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cjy OCA], [https://pdbe.org/9cjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cjy RCSB], [https://www.ebi.ac.uk/pdbsum/9cjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cjy ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Kanekiyo | + | == Function == |
| - | [[Category: Sangesland | + | [https://www.uniprot.org/uniprot/Q6WG00_9INFA Q6WG00_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS00204388] |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Influenza A virus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Macaca fascicularis]] | ||
| + | [[Category: Kanekiyo M]] | ||
| + | [[Category: Li N]] | ||
| + | [[Category: Sangesland M]] | ||
| + | [[Category: Tsybovsky Y]] | ||
Current revision
CryoEM structure of NC99 hemagglutinin trimer in complex with Fab BB798E 3-C07
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