9nrc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:27, 9 July 2025) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 9nrc is ON HOLD until Paper Publication
+
==TMPRSS6 in complex with REGN7999 Fab and REGN8023 Fab==
-
 
+
<StructureSection load='9nrc' size='340' side='right'caption='[[9nrc]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[9nrc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NRC FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.29&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nrc OCA], [https://pdbe.org/9nrc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nrc RCSB], [https://www.ebi.ac.uk/pdbsum/9nrc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nrc ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/TMPS6_HUMAN TMPS6_HUMAN] IRIDA syndrome. The disease is caused by variants affecting the gene represented in this entry. Mutations leading to abrogation of TMPRSS6 activity are associated with IRIDA due to elevated levels of hepcidin, a negative regulator of plasma iron pool (PubMed:20232450).<ref>PMID:20232450</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TMPS6_HUMAN TMPS6_HUMAN] Membrane-bound serine protease (PubMed:18976966, PubMed:20518742, PubMed:25156943, PubMed:25588876). Through the cleavage of cell surface hemojuvelin (HJV), a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed:18408718, PubMed:18976966, PubMed:25156943).<ref>PMID:18408718</ref> <ref>PMID:18976966</ref> <ref>PMID:20518742</ref> <ref>PMID:25156943</ref> <ref>PMID:25588876</ref> <ref>PMID:25156943</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Franklin MC]]
 +
[[Category: Saotome K]]

Current revision

TMPRSS6 in complex with REGN7999 Fab and REGN8023 Fab

PDB ID 9nrc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/9nrc"
Personal tools