9rp9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mouse pVHL-ElonginB-ElonginC complex== | |
| - | + | <StructureSection load='9rp9' size='340' side='right'caption='[[9rp9]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9rp9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RP9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> |
| - | [[Category: Biterova | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rp9 OCA], [https://pdbe.org/9rp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rp9 RCSB], [https://www.ebi.ac.uk/pdbsum/9rp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rp9 ProSAT]</span></td></tr> |
| - | [[Category: Blat | + | </table> |
| - | [[Category: Cukier | + | == Function == |
| + | [https://www.uniprot.org/uniprot/Q3TTE7_MOUSE Q3TTE7_MOUSE] Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR.[ARBA:ARBA00059036] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Biterova E]] | ||
| + | [[Category: Blat A]] | ||
| + | [[Category: Cukier C]] | ||
Current revision
Crystal structure of mouse pVHL-ElonginB-ElonginC complex
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