7nh9
From Proteopedia
(Difference between revisions)
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<StructureSection load='7nh9' size='340' side='right'caption='[[7nh9]], [[Resolution|resolution]] 3.03Å' scene=''> | <StructureSection load='7nh9' size='340' side='right'caption='[[7nh9]], [[Resolution|resolution]] 3.03Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NH9 FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.03Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.03Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nh9 OCA], [https://pdbe.org/7nh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nh9 RCSB], [https://www.ebi.ac.uk/pdbsum/7nh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nh9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nh9 OCA], [https://pdbe.org/7nh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nh9 RCSB], [https://www.ebi.ac.uk/pdbsum/7nh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nh9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == | + | <div style="background-color:#fffaf0;"> |
| - | + | == Publication Abstract from PubMed == | |
| + | The 2-TM-GxN family of membrane proteins is widespread in prokaryotes and plays an important role in transport of divalent cations. The canonical signature motif, which is also a selectivity filter, has a composition of Gly-Met-Asn. Some members though deviate from this composition, however no data are available as to whether this has any functional implications. Here we report the functional and structural analysis of CmaX protein from a pathogenic Pseudomonas aeruginosa bacterium, which has a Gly-Ile-Asn signature motif. CmaX readily transports Zn(2+), Mg(2+), Cd(2+), Ni(2+) and Co(2+) ions, but it does not utilize proton-symport as does ZntB from Escherichia coli. Together with the bioinformatics analysis, our data suggest that deviations from the canonical signature motif do not reveal any changes in substrate selectivity or transport and easily alter in course of evolution. | ||
| + | |||
| + | Structural and biochemical characterization of a novel ZntB (CmaX) transporter protein from Pseudomonas aeruginosa.,Stetsenko A, Stehantsev P, Dranenko NO, Gelfand MS, Guskov A Int J Biol Macromol. 2021 Jun 24;184:760-767. doi:, 10.1016/j.ijbiomac.2021.06.130. PMID:34175341<ref>PMID:34175341</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7nh9" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Pseudomonas aeruginosa PAO1]] | ||
[[Category: Guskov A]] | [[Category: Guskov A]] | ||
[[Category: Stehantsev P]] | [[Category: Stehantsev P]] | ||
[[Category: Stetsenko A]] | [[Category: Stetsenko A]] | ||
Current revision
structure of the full-length CmaX protein
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