8otx

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Current revision (16:52, 9 July 2025) (edit) (undo)
 
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== Function ==
== Function ==
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[https://www.uniprot.org/uniprot/A3RL54_STRPU A3RL54_STRPU]
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[https://www.uniprot.org/uniprot/SL9C1_STRPU SL9C1_STRPU] Electroneutral sodium:proton antiporter that regulates intracellular pH of sperm along with capacitation and fertility. Activated in response to egg-derived chemoattractants, couples membrane voltage to sodium:proton exchange and transduces membrane hyperpolarization to cytoplasmic alkalization to cAMP signaling and ultimately to sperm motility.<ref>PMID:30022052</ref> <ref>PMID:37880360</ref> <ref>PMID:37880361</ref>
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== References ==
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<references/>
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Current revision

Cryo-EM structure of Strongylocentrotus purpuratus sperm-specific Na+/H+ exchanger SLC9C1 in nanodisc

PDB ID 8otx

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