Nucleic acid-binding proteins
From Proteopedia
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Positively charged surface patches on proteins suggest possible binding sites for the negatively-charged phosphoribosyl backbones of DNA and RNA. Prediction of nucleic acid-binding sites on proteins has been well developed<ref>PMID: 40544633</ref>. | Positively charged surface patches on proteins suggest possible binding sites for the negatively-charged phosphoribosyl backbones of DNA and RNA. Prediction of nucleic acid-binding sites on proteins has been well developed<ref>PMID: 40544633</ref>. | ||
| - | [https://proteopedia.org/ | + | [https://proteopedia.org/wiki/index.php?Special:Search?search="dna-binding"&fulltext=Search] |
==References== | ==References== | ||
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Revision as of 13:37, 15 July 2025
Protein binding of nucleic acids is ubiquitous. Nucleic acids are synthesized, covalently modified, repaired and degraded by protein enzymes. Transcription factor proteins recognize specific DNA sequences to regulate gene expression. Ribosomal proteins bury themselves in RNA. Crucial for protein synthesis, aminoacyl t-RNA synthetases charge t-RNAs with specific amino acids.
Positively charged surface patches on proteins suggest possible binding sites for the negatively-charged phosphoribosyl backbones of DNA and RNA. Prediction of nucleic acid-binding sites on proteins has been well developed[1].
References
- ↑ Basu S, Yang Y, Kurgan L. Prediction of nucleic acid binding residues in protein sequences: Recent advances and future prospects. Curr Opin Struct Biol. 2025 Jun 21;94:103085. PMID:40544633 doi:10.1016/j.sbi.2025.103085
