9eza

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Current revision (06:44, 16 July 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9eza is ON HOLD
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==Interleukin-31 Receptor D1D2 in complex with Nemolizumab derived scFv==
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<StructureSection load='9eza' size='340' side='right'caption='[[9eza]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9eza]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EZA FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.147&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1H79:2-[bis(2-hydroxyethyl)amino]ethanesulfonic+acid'>A1H79</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9eza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9eza OCA], [https://pdbe.org/9eza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9eza RCSB], [https://www.ebi.ac.uk/pdbsum/9eza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9eza ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IL31R_HUMAN IL31R_HUMAN] Familial primary localized cutaneous amyloidosis. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/IL31R_HUMAN IL31R_HUMAN] Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15194700, PubMed:15627637). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).[UniProtKB:Q8K5B1]<ref>PMID:11877449</ref> <ref>PMID:14504285</ref> <ref>PMID:15184896</ref> <ref>PMID:15194700</ref> <ref>PMID:15627637</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Bloch Y]]
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[[Category: Savvides SN]]

Current revision

Interleukin-31 Receptor D1D2 in complex with Nemolizumab derived scFv

PDB ID 9eza

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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