1w8x

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[[Image:1w8x.gif|left|200px]]
[[Image:1w8x.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1w8x", creates the "Structure Box" on the page.
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{{STRUCTURE_1w8x| PDB=1w8x | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w8x OCA], [http://www.ebi.ac.uk/pdbsum/1w8x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w8x RCSB]</span>
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'''STRUCTURAL ANALYSIS OF PRD1'''
'''STRUCTURAL ANALYSIS OF PRD1'''
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[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
[[Category: Sutton, G C.]]
[[Category: Sutton, G C.]]
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[[Category: icosahedral virus]]
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[[Category: Icosahedral virus]]
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[[Category: p16 membrane protein]]
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[[Category: P16 membrane protein]]
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[[Category: p3 major capsid protein]]
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[[Category: P3 major capsid protein]]
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[[Category: p30 tape measure]]
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[[Category: P30 tape measure]]
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[[Category: p31 penton protein]]
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[[Category: P31 penton protein]]
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[[Category: virus/viral protein]]
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[[Category: Virus/viral protein]]
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Revision as of 10:19, 3 May 2008

Image:1w8x.gif

Template:STRUCTURE 1w8x

STRUCTURAL ANALYSIS OF PRD1


Overview

The structure of the membrane-containing bacteriophage PRD1 has been determined by X-ray crystallography at about 4 A resolution. Here we describe the structure and location of proteins P3, P16, P30 and P31. Different structural proteins seem to have specialist roles in controlling virus assembly. The linearly extended P30 appears to nucleate the formation of the icosahedral facets (composed of trimers of the major capsid protein, P3) and acts as a molecular tape-measure, defining the size of the virus and cementing the facets together. Pentamers of P31 form the vertex base, interlocking with subunits of P3 and interacting with the membrane protein P16. The architectural similarities with adenovirus and one of the largest known virus particles PBCV-1 support the notion that the mechanism of assembly of PRD1 is scaleable and applies across the major viral lineage formed by these viruses.

About this Structure

1W8X is a Protein complex structure of sequences from Enterobacteria phage prd1. Full crystallographic information is available from OCA.

Reference

Insights into assembly from structural analysis of bacteriophage PRD1., Abrescia NG, Cockburn JJ, Grimes JM, Sutton GC, Diprose JM, Butcher SJ, Fuller SD, San Martin C, Burnett RM, Stuart DI, Bamford DH, Bamford JK, Nature. 2004 Nov 4;432(7013):68-74. PMID:15525981 Page seeded by OCA on Sat May 3 13:19:17 2008

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