9jp0

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Current revision (07:07, 16 July 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9jp0 is ON HOLD until Paper Publication
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==the wild-type human PRMT1 filament==
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<StructureSection load='9jp0' size='340' side='right'caption='[[9jp0]], [[Resolution|resolution]] 3.68&Aring;' scene=''>
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Authors: Li, Y.W., Ru, Y.X.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9jp0]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JP0 FirstGlance]. <br>
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Description: the wild-type human PRMT1 filament
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.68&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jp0 OCA], [https://pdbe.org/9jp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jp0 RCSB], [https://www.ebi.ac.uk/pdbsum/9jp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jp0 ProSAT]</span></td></tr>
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[[Category: Ru, Y.X]]
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</table>
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[[Category: Li, Y.W]]
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== Function ==
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[https://www.uniprot.org/uniprot/ANM1_HUMAN ANM1_HUMAN] Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:10749851, PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).<ref>PMID:10749851</ref> <ref>PMID:11387442</ref> <ref>PMID:11448779</ref> <ref>PMID:12718890</ref> <ref>PMID:16879614</ref> <ref>PMID:18320585</ref> <ref>PMID:18657504</ref> <ref>PMID:18773938</ref> <ref>PMID:19124016</ref> <ref>PMID:19405910</ref> <ref>PMID:20442406</ref> <ref>PMID:25284789</ref> <ref>PMID:26575292</ref> <ref>PMID:26876602</ref> <ref>PMID:28040436</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Li YW]]
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[[Category: Ru YX]]

Current revision

the wild-type human PRMT1 filament

PDB ID 9jp0

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