9mr5

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m (Protected "9mr5" [edit=sysop:move=sysop])
Current revision (07:11, 16 July 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9mr5 is ON HOLD
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==Cryo-EM structure of human OATP1C1 F240A mutant in complex with estrone 3-glucuronide==
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<StructureSection load='9mr5' size='340' side='right'caption='[[9mr5]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9mr5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MR5 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.13&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E3G:ESTRONE+BETA-D-GLUCURONIDE'>E3G</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mr5 OCA], [https://pdbe.org/9mr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mr5 RCSB], [https://www.ebi.ac.uk/pdbsum/9mr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mr5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SO1C1_HUMAN SO1C1_HUMAN] Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed:12351693, PubMed:18566113, PubMed:19129463). Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed:18566113). Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed:18566113). Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed:12351693, PubMed:19129463). Transports T4 and E1S in a pH-insensitive manner (PubMed:19129463). Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed:30296914).<ref>PMID:12351693</ref> <ref>PMID:18566113</ref> <ref>PMID:19129463</ref> <ref>PMID:30296914</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ge Y]]
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[[Category: Huang P]]
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[[Category: Jiang J]]
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[[Category: Yadav GP]]

Current revision

Cryo-EM structure of human OATP1C1 F240A mutant in complex with estrone 3-glucuronide

PDB ID 9mr5

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