8h94

Structural highlights

Function

TLE6_MOUSE Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (PubMed:18804437, PubMed:25208553, PubMed:31575650, PubMed:37922900). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:31575650, PubMed:37922900). They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (PubMed:37922900). Also required for spermatogenesis: regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (PubMed:32823735, PubMed:39512902). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (PubMed:16314515). Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (PubMed:23990468).^{[1] [2] [3] [4] [5] [6] [7] [8]}

References

1. ↑ Marçal N, Patel H, Dong Z, Belanger-Jasmin S, Hoffman B, Helgason CD, Dang J, Stifani S. Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation. Mol Cell Biol. 2005 Dec;25(24):10916-29. PMID:16314515 doi:10.1128/MCB.25.24.10916-10929.2005
2. ↑ Li L, Baibakov B, Dean J. A subcortical maternal complex essential for preimplantation mouse embryogenesis. Dev Cell. 2008 Sep;15(3):416-425. PMID:18804437 doi:10.1016/j.devcel.2008.07.010
3. ↑ Kogawa M, Hisatake K, Atkins GJ, Findlay DM, Enoki Y, Sato T, Gray PC, Kanesaki-Yatsuka Y, Anderson PH, Wada S, Kato N, Fukuda A, Katayama S, Tsujimoto M, Yoda T, Suda T, Okazaki Y, Matsumoto M. The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation. J Biol Chem. 2013 Oct 25;288(43):31299-312. PMID:23990468 doi:10.1074/jbc.M113.461848
4. ↑ Yu XJ, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang ZB, Zheng P, Zhu MS, Wang H, Sun QY, Dean J, Li L. The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics. Nat Commun. 2014 Sep 11;5:4887. PMID:25208553 doi:10.1038/ncomms5887
5. ↑ Qin D, Gao Z, Xiao Y, Zhang X, Ma H, Yu X, Nie X, Fan N, Wang X, Ouyang Y, Sun QY, Yi Z, Li L. The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution. Development. 2019 Oct 18;146(20):dev183616. PMID:31575650 doi:10.1242/dev.183616
6. ↑ Feng M, Bai Y, Chen Y, Wang K. Knockout of the Transducin-Like Enhancer of Split 6 Gene Affects the Proliferation and Cell Cycle Process of Mouse Spermatogonia. Int J Mol Sci. 2020 Aug 13;21(16):5827. PMID:32823735 doi:10.3390/ijms21165827
7. ↑ Jentoft IMA, Bäuerlein FJB, Welp LM, Cooper BH, Petrovic A, So C, Penir SM, Politi AZ, Horokhovskyi Y, Takala I, Eckel H, Moltrecht R, Lénárt P, Cavazza T, Liepe J, Brose N, Urlaub H, Fernández-Busnadiego R, Schuh M. Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices. Cell. 2023 Nov 22;186(24):5308-5327.e25. PMID:37922900 doi:10.1016/j.cell.2023.10.003
8. ↑ Kazama K, Miyagoshi Y, Nishizono H. Tle6 deficiency in male mice led to abnormal sperm morphology and reduced sperm motility. Front Cell Dev Biol. 2024 Oct 24;12:1481659. PMID:39512902 doi:10.3389/fcell.2024.1481659