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8h94

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== Function ==
== Function ==
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[https://www.uniprot.org/uniprot/NALP5_MOUSE NALP5_MOUSE] As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:11062459, PubMed:18804437, PubMed:25208553). Required for the formation of F-actin cytoplasmic lattices (CPL) in oocytes, which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (PubMed:25208553). Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold (PubMed:31118423). Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy (PubMed:31118423). Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization (PubMed:24374158). May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation (PubMed:22357545).<ref>PMID:11062459</ref> <ref>PMID:18804437</ref> <ref>PMID:22357545</ref> <ref>PMID:24374158</ref> <ref>PMID:25208553</ref> <ref>PMID:31118423</ref>
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[https://www.uniprot.org/uniprot/TLE6_MOUSE TLE6_MOUSE] Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (PubMed:18804437, PubMed:25208553, PubMed:31575650, PubMed:37922900). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:31575650, PubMed:37922900). They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (PubMed:37922900). Also required for spermatogenesis: regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (PubMed:32823735, PubMed:39512902). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (PubMed:16314515). Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (PubMed:23990468).<ref>PMID:16314515</ref> <ref>PMID:18804437</ref> <ref>PMID:23990468</ref> <ref>PMID:25208553</ref> <ref>PMID:31575650</ref> <ref>PMID:32823735</ref> <ref>PMID:37922900</ref> <ref>PMID:39512902</ref>
== References ==
== References ==
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Current revision

Structure of mouse SCMC bound with KH domain of FILIA

PDB ID 8h94

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