Glutaminyl cyclase

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Current revision (09:27, 17 July 2025) (edit) (undo)
 
Line 21: Line 21:
*Glutaminyl cyclase
*Glutaminyl cyclase
-
**[[2afm]], [[2afo]] – hQC – human <br />
+
**[[2afm]], [[2afo]] – hQC + Zn – human <br />
-
**[[2afs]], [[2zed]], [[2zee]], [[2zef]], [[2zeg]], [[2zeh]], [[2zel]], [[2zem]], [[2zen]], [[2zeo]], [[2zep]], [[3pbe]], [[4yu9]], [[7cp0]] – hQC (mutant) <br />
+
**[[2afs]], [[2zed]], [[2zee]], [[2zef]], [[2zeg]], [[2zeh]], [[2zel]], [[2zem]], [[2zen]], [[2zeo]], [[2zep]], [[3pbe]], [[4yu9]], [[7cp0]] – hQC (mutant) + Zn<br />
-
**[[3pb4]], [[3pb6]] – hQC catalytic domain 28-382<br />
+
**[[9fxh]], [[9fxv]] – hQC (mutant) + Co<br />
-
**[[3si1]] – mQC – mouse <br />
+
**[[9fxg]] – hQC (mutant) <br />
-
**[[4fai]], [[4fwu]], [[4f9u]] – DmQC – ''Drosophila melanogaster'' <br />
+
**[[3pb4]], [[3pb6]] – hQC catalytic domain + Zn<br />
 +
**[[3si1]] – mQC + Zn – mouse <br />
 +
**[[4f9u]], [[4fai]], [[4fwu]] – DmQC – ''Drosophila melanogaster'' <br />
**[[4f9v]], [[4fbe]] – DmQC (mutant) <br />
**[[4f9v]], [[4fbe]] – DmQC (mutant) <br />
**[[2faw]] – QC – papaya<br />
**[[2faw]] – QC – papaya<br />
Line 38: Line 40:
**[[7d1b]] – QC – ''Fimbrilglobus ruber''<br />
**[[7d1b]] – QC – ''Fimbrilglobus ruber''<br />
**[[6qro]] – QC – ''Tannerella forsythia''<br />
**[[6qro]] – QC – ''Tannerella forsythia''<br />
 +
**[[8vpl]], [[8vpm]] – QC + Zn – ''Aspergillus flavus'' <br />
*Glutaminyl cyclase complex
*Glutaminyl cyclase complex
Line 43: Line 46:
**[[2afu]] – hQC + glutamine t-butyl ester <br />
**[[2afu]] – hQC + glutamine t-butyl ester <br />
**[[2afw]] – hQC + N-acetylhistamine <br />
**[[2afw]] – hQC + N-acetylhistamine <br />
-
**[[2afx]], [[3si0]], [[2afz]], [[3pb9]], [[7cm0]], [[7d8e]] – hQC catalytic domain + imidazole derivative<br />
+
**[[2afx]], [[3si0]], [[2afz]], [[3pb9]], [[7cm0]], [[7d8e]], [[8hy3]], [[8xfv]], [[8xga]], [[8xgb]], [[8xgt]], [[8xgy]], [[9isd]], [[9ivv]], [[9kmb]] – hQC catalytic domain + imidazole derivative + Zn<br />
 +
**[[9fxi]] – hQC (mutant) + inhibitor + Co<br />
**[[3pb7]], [[3pb8]], [[3pbb]] – hQC catalytic domain + inhibitor <br />
**[[3pb7]], [[3pb8]], [[3pbb]] – hQC catalytic domain + inhibitor <br />
**[[4ywy]], [[6gbx]], [[7coz]] – hQC (mutant) + inhibitor <br />
**[[4ywy]], [[6gbx]], [[7coz]] – hQC (mutant) + inhibitor <br />

Current revision

Structure of human glutaminyl cyclase complex with benzyimidazole and Zn+2 ion (PDB code 2afx).

Drag the structure with the mouse to rotate

3D Structures of glutaminyl cyclase

Updated on 17-July-2025

References

  1. ↑ Busby WH Jr, Quackenbush GE, Humm J, Youngblood WW, Kizer JS. An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes. J Biol Chem. 1987 Jun 25;262(18):8532-6. PMID:3597387
  2. ↑ Valenti MT, Bolognin S, Zanatta C, Donatelli L, Innamorati G, Pampanin M, Zanusso G, Zatta P, Dalle Carbonare L. Increased glutaminyl cyclase expression in peripheral blood of Alzheimer's disease patients. J Alzheimers Dis. 2013;34(1):263-71. doi: 10.3233/JAD-120517. PMID:23207485 doi:http://dx.doi.org/10.3233/JAD-120517
  3. ↑ Huang KF, Liu YL, Cheng WJ, Ko TP, Wang AH. Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13117-22. Epub 2005 Aug 31. PMID:16135565

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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