1zkz

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Revision as of 18:29, 12 November 2007

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spinqualitylabelsall models 1zkz, resolution 2.33Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal Structure of BMP9

Overview

Bone morphogenetic proteins (BMPs), a subset of the transforming growth, factor (TGF)-beta superfamily, regulate a diverse array of cellular, functions during development and in the adult. BMP-9 (also known as growth, and differentiation factor (GDF)-2) potently induces osteogenesis and, chondrogenesis, has been implicated in the differentiation of cholinergic, neurons, and may help regulate glucose metabolism. We have determined the, structure of BMP-9 to 2.3 A and examined the differences between our model, and existing crystal structures of other BMPs, both in isolation and in, complex with their receptors. TGF-beta ligands are translated as, precursors, with pro-regions that generally dissociate after cleavage from, the ligand, but in some cases (including GDF-8 and TGF-beta1, -2, and -3), the pro-region remains associated after secretion from the cell and, inhibits binding of the ligand to its receptor. Although the proregion of, BMP-9 remains tightly associated after secretion, we find, in several, cell-based assays, that the activities of BMP-9 and BMP-9.pro-region, complex were equivalent. Activin receptor-like kinase 1 (ALK-1), an orphan, receptor in the TGF-beta family, was also identified as a potential, receptor for BMP-9 based on surface plasmon resonance studies (BIAcore), and the ability of soluble ALK-1 to block the activity of BMP-9.pro-region, complex in cell-based assays.

About this Structure

1ZKZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of BMP-9 and functional interactions with pro-region and receptors., Brown MA, Zhao Q, Baker KA, Naik C, Chen C, Pukac L, Singh M, Tsareva T, Parice Y, Mahoney A, Roschke V, Sanyal I, Choe S, J Biol Chem. 2005 Jul 1;280(26):25111-8. Epub 2005 Apr 25. PMID:15851468

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