1w9x

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[[Image:1w9x.gif|left|200px]]
[[Image:1w9x.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1w9x |SIZE=350|CAPTION= <scene name='initialview01'>1w9x</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1w9x", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Ac1+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AC1:6-METHYL-5-(4,5,6-TRIHYDROXY-3-HYDROXYMETHYL-CYCLOHEX-2-ENYLAMINO)-TETRAHYDRO-PYRAN-2,3,4-TRIOL'>AC1</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1w9x| PDB=1w9x | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9x OCA], [http://www.ebi.ac.uk/pdbsum/1w9x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w9x RCSB]</span>
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}}
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'''BACILLUS HALMAPALUS ALPHA AMYLASE'''
'''BACILLUS HALMAPALUS ALPHA AMYLASE'''
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[[Category: Rasmussen, M D.]]
[[Category: Rasmussen, M D.]]
[[Category: Wilson, K S.]]
[[Category: Wilson, K S.]]
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[[Category: acarbose]]
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[[Category: Acarbose]]
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[[Category: amylase]]
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[[Category: Amylase]]
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[[Category: bacillus]]
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[[Category: Bacillus]]
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[[Category: glycoside hydrolase]]
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[[Category: Glycoside hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:21:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:33:17 2008''
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Revision as of 10:21, 3 May 2008

Image:1w9x.gif

Template:STRUCTURE 1w9x

BACILLUS HALMAPALUS ALPHA AMYLASE


Overview

The enzymatic digestion of starch by alpha-amylases is one of the key biotechnological reactions of recent times. In the search for industrial biocatalysts, the family GH13 alpha-amylase BHA from Bacillus halmapalus has been cloned and expressed. The three-dimensional structure at 2.1 A resolution has been determined in complex with the (pseudo)tetrasaccharide inhibitor acarbose. Acarbose is found bound as a nonasaccharide transglycosylation product spanning the -6 to +3 subsites. Careful inspection of electron density suggests that the bound ligand could not have been formed through successive transglycosylations of acarbose and must also have featured maltose or maltooligosaccharides as an acceptor.

About this Structure

1W9X is a Single protein structure of sequence from Bacillus halmapalus. Full crystallographic information is available from OCA.

Reference

Structure of a Bacillus halmapalus family 13 alpha-amylase, BHA, in complex with an acarbose-derived nonasaccharide at 2.1 A resolution., Davies GJ, Brzozowski AM, Dauter Z, Rasmussen MD, Borchert TV, Wilson KS, Acta Crystallogr D Biol Crystallogr. 2005 Feb;61(Pt 2):190-3. Epub 2005, Jan 19. PMID:15681870 Page seeded by OCA on Sat May 3 13:21:41 2008

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OCA

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