1wa5

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[[Image:1wa5.gif|left|200px]]
[[Image:1wa5.gif|left|200px]]
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{{Structure
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|PDB= 1wa5 |SIZE=350|CAPTION= <scene name='initialview01'>1wa5</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1wa5", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GTP:GUANOSINE-5&#39;-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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{{STRUCTURE_1wa5| PDB=1wa5 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wa5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wa5 OCA], [http://www.ebi.ac.uk/pdbsum/1wa5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wa5 RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE EXPORTIN CSE1P COMPLEXED WITH ITS CARGO (KAP60P) AND RANGTP'''
'''CRYSTAL STRUCTURE OF THE EXPORTIN CSE1P COMPLEXED WITH ITS CARGO (KAP60P) AND RANGTP'''
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[[Category: Matsuura, Y.]]
[[Category: Matsuura, Y.]]
[[Category: Stewart, M.]]
[[Category: Stewart, M.]]
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[[Category: exportin]]
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[[Category: Exportin]]
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[[Category: importin alpha]]
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[[Category: Importin alpha]]
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[[Category: nuclear transport]]
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[[Category: Nuclear transport]]
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[[Category: protein transport]]
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[[Category: Protein transport]]
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[[Category: ran gtpase]]
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[[Category: Ran gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:22:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:33:22 2008''
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Revision as of 10:22, 3 May 2008

Image:1wa5.gif

Template:STRUCTURE 1wa5

CRYSTAL STRUCTURE OF THE EXPORTIN CSE1P COMPLEXED WITH ITS CARGO (KAP60P) AND RANGTP


Overview

The nuclear import and export of macromolecular cargoes through nuclear pore complexes is mediated primarily by carriers such as importin-beta. Importins carry cargoes into the nucleus, whereas exportins carry cargoes to the cytoplasm. Transport is orchestrated by nuclear RanGTP, which dissociates cargoes from importins, but conversely is required for cargo binding to exportins. Here we present the 2.0 A crystal structure of the nuclear export complex formed by exportin Cse1p complexed with its cargo (Kap60p) and RanGTP, thereby providing a structural framework for understanding nuclear protein export and the different functions of RanGTP in export and import. In the complex, Cse1p coils around both RanGTP and Kap60p, stabilizing the RanGTP-state and clamping the Kap60p importin-beta-binding domain, ensuring that only cargo-free Kap60p is exported. Mutagenesis indicated that conformational changes in exportins couple cargo binding to high affinity for RanGTP, generating a spring-loaded molecule to facilitate disassembly of the export complex following GTP hydrolysis in the cytoplasm.

About this Structure

1WA5 is a Protein complex structure of sequences from Canis lupus familiaris and Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1WA5 with [Importins]. Full crystallographic information is available from OCA.

Reference

Structural basis for the assembly of a nuclear export complex., Matsuura Y, Stewart M, Nature. 2004 Dec 16;432(7019):872-7. PMID:15602554 Page seeded by OCA on Sat May 3 13:22:17 2008

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