1wa8
From Proteopedia
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'''SOLUTION STRUCTURE OF THE CFP-10.ESAT-6 COMPLEX. MAJOR VIRULENCE DETERMINANTS OF PATHOGENIC MYCOBACTERIA''' | '''SOLUTION STRUCTURE OF THE CFP-10.ESAT-6 COMPLEX. MAJOR VIRULENCE DETERMINANTS OF PATHOGENIC MYCOBACTERIA''' | ||
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[[Category: Veverka, V.]] | [[Category: Veverka, V.]] | ||
[[Category: Williamson, R A.]] | [[Category: Williamson, R A.]] | ||
| - | [[Category: | + | [[Category: Protein structure initiative]] |
| - | [[Category: | + | [[Category: Psi]] |
| - | [[Category: | + | [[Category: Psi,protein structure initiative,tb structural genomics consortium]] |
| - | [[Category: | + | [[Category: Tbsgc]] |
| - | [[Category: | + | [[Category: Tuberculosis,cfp-10,esat-6,helix-turn-helix,four helix bundle,mycobacteria,pathogenesis,nmr,solution structure]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:22:34 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 10:22, 3 May 2008
SOLUTION STRUCTURE OF THE CFP-10.ESAT-6 COMPLEX. MAJOR VIRULENCE DETERMINANTS OF PATHOGENIC MYCOBACTERIA
Overview
The secreted Mycobacterium tuberculosis complex proteins CFP-10 and ESAT-6 have recently been shown to play an essential role in tuberculosis pathogenesis. We have determined the solution structure of the tight, 1:1 complex formed by CFP-10 and ESAT-6, and employed fluorescence microscopy to demonstrate specific binding of the complex to the surface of macrophage and monocyte cells. A striking feature of the complex is the long flexible arm formed by the C-terminus of CFP-10, which was found to be essential for binding to the surface of cells. The surface features of the CFP-10.ESAT-6 complex, together with observed binding to specific host cells, strongly suggest a key signalling role for the complex, in which binding to cell surface receptors leads to modulation of host cell behaviour to the advantage of the pathogen.
About this Structure
1WA8 is a Protein complex structure of sequences from Mycobacterium bovis and Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6., Renshaw PS, Lightbody KL, Veverka V, Muskett FW, Kelly G, Frenkiel TA, Gordon SV, Hewinson RG, Burke B, Norman J, Williamson RA, Carr MD, EMBO J. 2005 Jul 20;24(14):2491-8. Epub 2005 Jun 23. PMID:15973432 Page seeded by OCA on Sat May 3 13:22:34 2008
Categories: Mycobacterium bovis | Mycobacterium tuberculosis | Protein complex | Burke, B. | Carr, M D. | Frenkiel, T A. | Gordon, S V. | Hewinson, R G. | Kelly, G. | Lightbody, K L. | Muskett, F W. | Norman, J. | Renshaw, P S. | TBSGC, TB Structural Genomics Consortium. | Veverka, V. | Williamson, R A. | Protein structure initiative | Psi | Psi,protein structure initiative,tb structural genomics consortium | Tbsgc | Tuberculosis,cfp-10,esat-6,helix-turn-helix,four helix bundle,mycobacteria,pathogenesis,nmr,solution structure
