1wac

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[[Image:1wac.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wac OCA], [http://www.ebi.ac.uk/pdbsum/1wac PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wac RCSB]</span>
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'''BACK-PRIMING MODE OF PHI6 RNA-DEPENDENT RNA POLYMERASE'''
'''BACK-PRIMING MODE OF PHI6 RNA-DEPENDENT RNA POLYMERASE'''
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[[Category: Salgado, P S.]]
[[Category: Salgado, P S.]]
[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
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[[Category: phi6 rna-dependent rna polymerase]]
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[[Category: Phi6 rna-dependent rna polymerase]]
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[[Category: transcription]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:22:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:33:28 2008''
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Revision as of 10:22, 3 May 2008

Image:1wac.gif

Template:STRUCTURE 1wac

BACK-PRIMING MODE OF PHI6 RNA-DEPENDENT RNA POLYMERASE


Overview

The RNA-dependent RNA polymerase of the double-stranded RNA bacteriophage phi6 is capable of primer-independent initiation, as are many RNA polymerases. The structure of this polymerase revealed an initiation platform, composed of a loop in the C-terminal domain (QYKW, aa 629-632), that was essential for de novo initiation. A similar element has been identified in hepatitis C virus RNA-dependent RNA polymerase. Biochemical studies have addressed the role of this platform, revealing that a mutant version can utilize a back-priming initiation mechanism, where the 3' terminus of the template adopts a hairpin-like conformation. Here, the mechanism of back-primed initiation is studied further by biochemical and structural methods.

About this Structure

1WAC is a Single protein structure of sequence from Pseudomonas phage phi6. Full crystallographic information is available from OCA.

Reference

Back-priming mode of phi6 RNA-dependent RNA polymerase., Laurila MR, Salgado PS, Stuart DI, Grimes JM, Bamford DH, J Gen Virol. 2005 Feb;86(Pt 2):521-6. PMID:15659773 Page seeded by OCA on Sat May 3 13:22:49 2008

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