1wbe

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[[Image:1wbe.gif|left|200px]]
[[Image:1wbe.gif|left|200px]]
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{{Structure
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|PDB= 1wbe |SIZE=350|CAPTION= <scene name='initialview01'>1wbe</scene>, resolution 1.36&Aring;
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The line below this paragraph, containing "STRUCTURE_1wbe", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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{{STRUCTURE_1wbe| PDB=1wbe | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wbe OCA], [http://www.ebi.ac.uk/pdbsum/1wbe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wbe RCSB]</span>
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'''X-RAY STRUCTURE OF BOVINE GLTP'''
'''X-RAY STRUCTURE OF BOVINE GLTP'''
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[[Category: Salminen, T A.]]
[[Category: Salminen, T A.]]
[[Category: West, G.]]
[[Category: West, G.]]
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[[Category: acetylation]]
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[[Category: Acetylation]]
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[[Category: glycolipid transfer]]
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[[Category: Glycolipid transfer]]
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[[Category: lipid transport]]
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[[Category: Lipid transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:25:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:33:52 2008''
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Revision as of 10:25, 3 May 2008

Image:1wbe.gif

Template:STRUCTURE 1wbe

X-RAY STRUCTURE OF BOVINE GLTP


Overview

Glycolipids participate in many important cellular processes and they are bound and transferred with high specificity by glycolipid transfer protein (GLTP). We have solved three different X-ray structures of bovine GLTP at 1.4 angstroms, 1.6 angstroms and 1.8 angstroms resolution, all with a bound fatty acid or glycolipid. The 1.4 angstroms structure resembles the recently characterized apo-form of the human GLTP but the other two structures represent an intermediate conformation of the apo-GLTPs and the human lactosylceramide-bound GLTP structure. These novel structures give insight into the mechanism of lipid binding and how GLTP may conformationally adapt to different lipids. Furthermore, based on the structural comparison of the GLTP structures and the three-dimensional models of the related Podospora anserina HET-C2 and Arabidopsis thaliana accelerated cell death protein, ACD11, we give structural explanations for their specific lipid binding properties.

About this Structure

1WBE is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural evidence for adaptive ligand binding of glycolipid transfer protein., Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA, J Mol Biol. 2006 Jan 13;355(2):224-36. Epub 2005 Nov 8. PMID:16309699 Page seeded by OCA on Sat May 3 13:25:10 2008

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