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1wco
From Proteopedia
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[[Image:1wco.gif|left|200px]] | [[Image:1wco.gif|left|200px]] | ||
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'''THE SOLUTION STRUCTURE OF THE NISIN-LIPID II COMPLEX''' | '''THE SOLUTION STRUCTURE OF THE NISIN-LIPID II COMPLEX''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1WCO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis] and [http://en.wikipedia.org/wiki/Monarthropalpus_flavus Monarthropalpus flavus]. This structure supersedes the now removed PDB entry | + | 1WCO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis] and [http://en.wikipedia.org/wiki/Monarthropalpus_flavus Monarthropalpus flavus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1uzt 1uzt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Nuland, N A.J Van.]] | [[Category: Nuland, N A.J Van.]] | ||
[[Category: Tischenko, E.]] | [[Category: Tischenko, E.]] | ||
| - | [[Category: | + | [[Category: Antibiotic]] |
| - | [[Category: | + | [[Category: Peptidoglycan]] |
| - | [[Category: | + | [[Category: Pore formation]] |
| - | [[Category: | + | [[Category: Pyrophosphate cage]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:28:26 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 10:28, 3 May 2008
THE SOLUTION STRUCTURE OF THE NISIN-LIPID II COMPLEX
Overview
The emerging antibiotics-resistance problem has underlined the urgent need for novel antimicrobial agents. Lantibiotics (lanthionine-containing antibiotics) are promising candidates to alleviate this problem. Nisin, a member of this family, has a unique pore-forming activity against bacteria. It binds to lipid II, the essential precursor of cell wall synthesis. As a result, the membrane permeabilization activity of nisin is increased by three orders of magnitude. Here we report the solution structure of the complex of nisin and lipid II. The structure shows a novel lipid II-binding motif in which the pyrophosphate moiety of lipid II is primarily coordinated by the N-terminal backbone amides of nisin via intermolecular hydrogen bonds. This cage structure provides a rationale for the conservation of the lanthionine rings among several lipid II-binding lantibiotics. The structure of the pyrophosphate cage offers a template for structure-based design of novel antibiotics.
About this Structure
1WCO is a Single protein structure of sequence from Lactococcus lactis and Monarthropalpus flavus. This structure supersedes the now removed PDB entry 1uzt. Full crystallographic information is available from OCA.
Reference
The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics., Hsu ST, Breukink E, Tischenko E, Lutters MA, de Kruijff B, Kaptein R, Bonvin AM, van Nuland NA, Nat Struct Mol Biol. 2004 Oct;11(10):963-7. Epub 2004 Sep 12. PMID:15361862 Page seeded by OCA on Sat May 3 13:28:26 2008
