9jj9

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'''Unreleased structure'''
 
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The entry 9jj9 is ON HOLD until Paper Publication
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==Class 3 state of the GfsA KSQ-ancestralAT chimeric didomain in complex with the GfsA ACP domain==
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<StructureSection load='9jj9' size='340' side='right'caption='[[9jj9]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9jj9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_graminofaciens Streptomyces graminofaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JJ9 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9EF:N-[2-(acetylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide'>9EF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jj9 OCA], [https://pdbe.org/9jj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jj9 RCSB], [https://www.ebi.ac.uk/pdbsum/9jj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jj9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GFSA_STRHA GFSA_STRHA] First protein in the synthesis of the 16-membered macrolide antibiotics FD-891 and FD-892 (PubMed:20589823). Composed of 5 modules; the first is a loading module (LM) that synthesizes a starter unit used by the first elongation module for polyketide chain elongation (PubMed:34985877, PubMed:37216195). The starter unit is extended by multiple rounds of addition of malonyl-CoA or methylmalonyl-CoA, and other modifications to help generate the final products (Probable) (PubMed:20589823). The loading module (residues 1-927, LM with an inactive acyltransferase domain) preferentially decarboxylates malonyl-GfsA acyl carrier protein of the LM (ACP-LM) over methylmalonyl-GfsA ACP-LM and has no activity on malonyl-CoA or methymalonyl-CoA (PubMed:34985877). LM decarboxylates malonyl-ACP-LM better than the malonyl-ACP-1 module of GfsA (i.e. the next module in the same protein) and has no activity on other malonyl-ACP modules (PubMed:37216195).<ref>PMID:20589823</ref> <ref>PMID:34985877</ref> <ref>PMID:37216195</ref> <ref>PMID:20589823</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Streptomyces graminofaciens]]
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[[Category: Adachi N]]
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[[Category: Chisuga T]]
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[[Category: Eguchi T]]
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[[Category: Kawasaki M]]
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[[Category: Kudo F]]
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[[Category: Liao Z]]
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[[Category: Miyanaga A]]
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[[Category: Moriya T]]
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[[Category: Senda T]]

Revision as of 05:42, 6 August 2025

Class 3 state of the GfsA KSQ-ancestralAT chimeric didomain in complex with the GfsA ACP domain

PDB ID 9jj9

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OCA

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