9k3p

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Current revision (05:45, 6 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9k3p is ON HOLD until Paper Publication
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==Cryo-EM structure of the unliganded human melanocortin receptor 1 (MC1R)-Gs complex==
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<StructureSection load='9k3p' size='340' side='right'caption='[[9k3p]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
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Authors: Feng, W.B., Zhou, Q.T., Zheng, C., Yang, D.H., Wang, M.W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9k3p]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9K3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9K3P FirstGlance]. <br>
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Description: Cryo-EM structure of the unliganded human melanocortin receptor 1 (MC1R)-Gs complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.98&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9k3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9k3p OCA], [https://pdbe.org/9k3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9k3p RCSB], [https://www.ebi.ac.uk/pdbsum/9k3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9k3p ProSAT]</span></td></tr>
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[[Category: Zheng, C]]
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</table>
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[[Category: Zhou, Q.T]]
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== Disease ==
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[[Category: Feng, W.B]]
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[https://www.uniprot.org/uniprot/MSHR_HUMAN MSHR_HUMAN] Familial melanoma;Oculocutaneous albinism type 2. Disease susceptibility is associated with variants affecting the gene represented in this entry.
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[[Category: Yang, D.H]]
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== Function ==
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[[Category: Wang, M.W]]
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[https://www.uniprot.org/uniprot/MSHR_HUMAN MSHR_HUMAN] Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:11442765, PubMed:11707265, PubMed:1325670, PubMed:1516719, PubMed:8463333). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11707265, PubMed:1325670, PubMed:16463023, PubMed:19737927). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585).<ref>PMID:11442765</ref> <ref>PMID:11707265</ref> <ref>PMID:1325670</ref> <ref>PMID:1516719</ref> <ref>PMID:16463023</ref> <ref>PMID:19737927</ref> <ref>PMID:31097585</ref> <ref>PMID:8463333</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bos taurus]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Feng WB]]
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[[Category: Wang MW]]
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[[Category: Yang DH]]
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[[Category: Zheng C]]
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[[Category: Zhou QT]]

Current revision

Cryo-EM structure of the unliganded human melanocortin receptor 1 (MC1R)-Gs complex

PDB ID 9k3p

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