9mxj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human Vault Cage in complex with ADP-ribose== | |
| - | + | <StructureSection load='9mxj' size='340' side='right'caption='[[9mxj]], [[Resolution|resolution]] 3.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9mxj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MXJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.49Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mxj OCA], [https://pdbe.org/9mxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mxj RCSB], [https://www.ebi.ac.uk/pdbsum/9mxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mxj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MVP_HUMAN MVP_HUMAN] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.<ref>PMID:15133037</ref> <ref>PMID:16441665</ref> <ref>PMID:16418217</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lodwick JE]] | ||
| + | [[Category: Zhao M]] | ||
Current revision
Human Vault Cage in complex with ADP-ribose
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