8zuj

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m (Protected "8zuj" [edit=sysop:move=sysop])
Current revision (05:59, 6 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8zuj is ON HOLD
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==Pentagonal cluster of BAFF-BAFFR ectodomain complex==
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<StructureSection load='8zuj' size='340' side='right'caption='[[8zuj]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
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Authors: Lim, C.S., Lee, J.O.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8zuj]] is a 30 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZUJ FirstGlance]. <br>
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Description: Pentagonal cluster of BAFF-BAFFR ectodomain complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.58&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zuj OCA], [https://pdbe.org/8zuj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zuj RCSB], [https://www.ebi.ac.uk/pdbsum/8zuj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zuj ProSAT]</span></td></tr>
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[[Category: Lee, J.O]]
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</table>
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[[Category: Lim, C.S]]
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== Disease ==
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[https://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN] Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:[https://omim.org/entry/613494 613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:19666484</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN] B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.<ref>PMID:11591325</ref> <ref>PMID:12387744</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Lee JO]]
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[[Category: Lim CS]]

Current revision

Pentagonal cluster of BAFF-BAFFR ectodomain complex

PDB ID 8zuj

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