GTPase KRas 3D structures

From Proteopedia

Revision as of 08:30, 6 August 2025

3D Structures of GTPase KRas

Updated on 06-August-2025 {{#tree:id=OrganizedByTopic|openlevels=0|

• GTPase KRas binary complex with nucleotide

• • 5uk9 – hKRas + GCP + GDP – human
    
  • 5vq2 – hKRas + GTP
    
  • 5vpi, 5vpz, 5vq6, 6mnx – hKRas (mutant) + GTP
    
  • 3gft, 6mta – hKRas (mutant) + GTP analog
    
  • 6god, 6mbq – hKRas + GNP
    
  • 5usj, 5vpy, 6e6f, 6goe, 6gof, 6gog, 6gom, 6o36, 6o46, 8ebz – hKRas (mutant) + GNP
    
  • 4lkp, 4obe, 5vq8, 5w22, 6mbt, 6mbu, 6p0z, 7tlk – hKRas + GDP
    
  • 4l8g, 4ldj, 4lrw, 4ql3, 4tq9, 4wa7, 5uqw, 5us4, 5vp7, 5vq0, 5vq1, 5whd, 6asa, 6ase, 6bof, 6e6g, 6mqg, 6mqn, 6ms9, 6pq3, 6ws2, 6ws4, 7c40, 7eyx, 7f0w, 7kmr, 8fmi, 8fmj, 8fmk, 8g4f, 8stm, 8stn, 8tvk, 8txj, 8ty2, 8ty8, 8ty9 – hKRas (mutant) + GDP
    
  • 7g42, 8g47, 8g4h – hKRas (mutant) + GDP – Cryo EM
    
  • 7lgi – hKRas + GDP - NMR
    
  • 9o0r, 9o0s – hKRas + drug + GDP
    
  • 9dmm – hKRas (mutant) + drug + GDP
    
  • 7mqu – hKRas + drug + GDP - NMR
    
  • 4dsn, 6bp1, 6quu – hKRas (mutant) + GCP
    
  • 7lz5 – hKRas (mutant) + GMPPCP
    

• GTPase KRas complex with inhibitor

• • 4dso – hKRas (mutant) + inhibitor + GSP
    
  • 4dst, 6gj5, 6gj6, 6gj7, 6gj8, 6quv, 6quw, 6qux – hKRas (mutant) + inhibitor + GCP
    
  • 5kyk – hKRas + inhibitor
    
  • 4nmm, 7ok3, 7ok4 – hKRas (mutant) + inhibitor
    
  • 6v5l, 7tle, 8afb, 8afc, 8afd, 8azr, 8azv, 8jhl, 8onv, 8s8c, 9bai, 9bak, 9baj, 9qpz – hKRas + GDP + inhibitor
    
  • 4dsu, 4luc, 4lv6, 4lyf, 4lyh, 4lyj, 4m1o, 4m1s, 4m1t, 4m1w, 4m1y, 4m21, 4m22, 4epr, 4ept, 4epv, 4epw, 4epx, 4epy, 4q01, 4q02, 4q03, 4pzy, 4pzz, 5f2e, 5vbm, 5v6s, 5v6v, 5v9o, 5v9u, 5xco, 5yxz, 5yy1, 6ark, 6b0v, 6b0y, 6n2j, 6n2k, 6oim, 6p8w, 6p8x, 6p8y, 6p8z, 6pgo, 6pgp, 6t5b, 6tam, 6tan, 6usx, 6usz, 6ut0, 6zl5, 7a1w, 7a1x, 7a1y, 7a47, 7acq, 7ew9, 7ewa, 7ewb, 7o70, 7oo7, 7r0m, 7r0n, 7r0q, 7rp4, 7tlg, 7u8h, 7ycc, 7yce, 8aq5, 8aq7, 8azx, 8azy, 8azz, 8b00, 8b6i, 8b78, 8cx5, 8dni, 8dnj, 8dnk, 8qug, 8r7w, 8r7x, 8t4v, 8txe, 8txg, 8txh, 8txk, 8un3, 8un4, 8un5, 8v3a, 8wb1, 8x6r, 9bl0, 9e5d, 9e5f, 9e9h, 9e9i, 9gbj, 9kpn, 9u50, 9u5t – hKRas (mutant) + GDP + inhibitor
    
  • 5ocg, 5oco, 5oct, 5vbz, 6f76, 6fa1, 6fa2, 6fa3, 6fa4, 6gqt, 6gqx, 6gqw, 6gqy, 8jgd, 8v39 – hKRas (mutant) + GNP + inhibitor
    
  • 6zli – hKRas (mutant) + GCP + inhibitor
    
  • 7aca, 7acf, 7ach, 7t47 – hKRas (mutant) + GPPCP + inhibitor
    
  • 9usb – hKRas (mutant) + GPPNP + inhibitor
    
  • 5v71, 5v9l, 6t5v – hKRas (mutant) + GDP + quinazoline inhibitor
    

• GTPase KRas complex with protein

• • 5wha, 5whb – hKRas (mutant) + miniprotein + GDP
    
  • 5whe, 5wlb, 5wpl, 5wpm – hKRas (mutant) + miniprotein + GNP
    
  • 6h46 – hKRas + darpin K13 + GDP
    
  • 6h47 – hKRas + darpin K19
    
  • 5mlb, 5o2s – hKRas + darpin K27 + GDP
    
  • 5mla, 5o2t – hKRas + darpin 55 + GSP
    
  • 7scw, 7scx – hKRas (mutant) + RALGDS-like + GSP
    
  • 5o2s, 5ufe – hKRas + R11.1.6 + GNP
    
  • 5ufq – hKRas (mutant) + R11.1.6 + GNP
    
  • 6wgn – hKRas (mutant) + peptide inhibitor + GNP
    
  • 9c15, 9cmv – hKRas + p110 alpha + GNP
    
  • 7c41, 7w5r, 7yuz – hKRas (mutant) + peptide inhibitor + GDP
    
  • 7mdp, 7rp2, 7rp3 – hKRas (mutant) + antibody + GDP
    
  • 7yv1, 8vgq – hKRas (mutant) + antibody + inhibitor + GDP
    
  • 8be3, 8ezg – hKRas (mutant) + nanobody + GDP
    
  • 8f0m – hKRas (mutant) + monobody + GDP
    
  • 8be4, 8be5 – hKRas (mutant) + nanobody + son of sevenless + GDP
    

• • 7rov – hKRas (mutant) + peptide inhibitor + GMPPCP
    
  • 8jjs – hKRas (mutant) + peptide inhibitor + GDP
    

• • 2msc, 2msd – hKRas + apolipoprotein + GDP - NMR
    
  • 2mse – hKRas + apolipoprotein + A-Raf + GDP - NMR
    
  • 8dgt – hKRas + MKK1 + B-Raf + 14-3-3 protein zeta + ATPgS – Cryo EM
    
  • 6xgu, 6xgv – hKRas (mutant) + C-Raf + GNP
    
  • 6pts, 6ptw – hKRas + apolipoprotein + C-Raf + GNP - NMR
    
  • 6cc9, 6cch, 6ccx – hKRas (mutant) + apolipoprotein + inhibitor + GNP - NMR
    
  • 6epl – hKRas (mutant) + son of sevenless homolog 1
    
  • 7kfz – hKRas (mutant) + son of sevenless homolog 1 + GNP
    
  • 6epm, 6epn, 6epo, 6epp – hKRas (mutant) + son of sevenless homolog 1 + inhibitor
    
  • 6ob2 – hKRas + neurofibromin + GNP
    
  • 6ob3 – hKRas (mutant) + neurofibromin + GNP
    
  • 8qvu, 8qw6, 8qw7 – hKRas (mutant) + elongin B,C + pVHL + GDP
    
  • 8qu8 – hKRas + elongin B,C + pVHL + cullin-2 + Rbx1 + inhibitor + GDP – Cryo EM
    
  • 6v65, 6v6f – hKRas + neurofibromin + Hspred1 + GNP
    
  • 6yr8, 6yxw, 7ny8 – hKRas + affirmer K6 + GDP
    
  • 9bgh, 9bho, 9bhp, 9bhq – hKRas (mutant) + PPIASE + inhibitor + GDP
    
  • 8g9p, 8g9q, 8tbf, 8tbh, 8tbj, 8tbk, 8tbl, 8tbm, 8tbn, 9ax6, 9bfv, 9bfw, 9bfx, 9bfy, 9bfz, 9bg1, 9bg2, 9bg4, 9bg7, 9bi1, 9bi2, 9ct7, 9e3s – hKRas (mutant) + PPIASE + inhibitor + GNP
    
  • 9bg5, 9bg6, 9bga, 9bgb, 9bgc, 9ct8, 9ct9, 9cta, 9ctb – hKRas (mutant) + PPIASE + drug + GNP
    
  • 8rro – hKRas + Tcr + HLA + microglobulin + drug + GNP
    
  • 6t5u – KRas (mutant) + V-ki-ras2 + inhibitor + GDP -hedgehog
    

• GTPase KRas4A

• • 8t72 – hKRas + PNP
    
  • 8t71 – hKRas + GDP
    
  • 8t73 – hKRas (mutant) + GDP
    
  • 8t75 – hKRas + C-Raf + PNP
    
  • 8t74 – hKRas + Raf1 + PNP
    
  • 7vvb – hKRas + SIN1 + PNP
    
  • [[9g0y, 9g4b, 9ggt, 9ggu, 9ggv, 9ggw, 9ggx, 9ggy, 9ggz, 9gh0, 9gh1, 9gh2 – hKRas + GDP + inhibitor
    

• GTPase KRas2B

• • 7kyz – hKRas + GDP - NMR
    
  • 9gtk – hKRas + Darpin + GDP
    

• GTPase KRas4B

• • 6m9w, 8ecr – hKRas + GDP
    
  • 6w4e – hKRas + GDP - NMR
    
  • 7t1f, 8blr, 8cpr, 8edy, 8eer – hKRas (mutant) + GDP
    
  • 6vc8 – hKRas + PNP
    
  • 6cu6 – hKRas (mutant) + PNP
    
  • 8eie – hKRas + GNP
    
  • 5tar, 5tb5, 7q9u – hKRas + GMP-PDE d + farnesyl + GDP <br
  • 8b69 – hKRas (mutant) + Rgl2 + GNP
    
  • 6w4e – hKRas + apolipoprotein + GTP - NMR
    
  • 6w4f – hKRas + apolipoprotein + GDP - NMR
    
  • 7rsc, 7rse – hKRas (mutant) + apolipoprotein + GSP - NMR
    
  • 6vjj, 6xhb, 6xi7 – hKRas + Raf1/CRaf + GNP
  • 6xha, 8epw – hKRas (mutant) + Raf1/CRaf + PNP
  • 7lc1, 7lc2 – hKRas (mutant) + SIN1+ GNP
    
  • 7rpz, 7rt1, 7rt2, 7rt3, 7rt4, 7rt5, 9kpm, 9kpn – hKRas (mutant) + GDP + inhibitor
    

• GTPase KRasX2

• • 8dgs, 8dgt – hKRas + MKK1 + B-Raf + 14-3-3 protein zeta + ATPgS – Cryo EM
    

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