8ykd
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of ADGRG2-Gs complex with NTF nanobody== | |
| - | + | <StructureSection load='8ykd' size='340' side='right'caption='[[8ykd]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ykd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Spodoptera Spodoptera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YKD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AND:3-BETA-HYDROXY-5-ANDROSTEN-17-ONE'>AND</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ykd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ykd OCA], [https://pdbe.org/8ykd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ykd RCSB], [https://www.ebi.ac.uk/pdbsum/8ykd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ykd ProSAT]</span></td></tr> |
| - | [[Category: Huang | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AGRG2_MOUSE AGRG2_MOUSE] Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as dehydroepiandrosterone (DHEA; also named 3beta-hydroxyandrost-5-en-17-one) and androstenedione (PubMed:35982227). Involved in a signal transduction pathway controlling epididymal function and male fertility (PubMed:15367682). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:35982227). ADGRG2 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:35982227). Also able to couple with G(q) G proteins in vitro (PubMed:35982227). May regulate fluid exchange within epididymis (PubMed:15367682).<ref>PMID:15367682</ref> <ref>PMID:35982227</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Spodoptera]] | ||
| + | [[Category: Huang SM]] | ||
| + | [[Category: Sheng-chao G]] | ||
Current revision
Cryo-EM structure of ADGRG2-Gs complex with NTF nanobody
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