1weh
From Proteopedia
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'''Crystal structure of the conserved hypothetical protein TT1887 from Thermus thermophilus HB8''' | '''Crystal structure of the conserved hypothetical protein TT1887 from Thermus thermophilus HB8''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WEH OCA]. | |
==Reference== | ==Reference== | ||
Crystal structures of possible lysine decarboxylases from Thermus thermophilus HB8., Kukimoto-Niino M, Murayama K, Kato-Murayama M, Idaka M, Bessho Y, Tatsuguchi A, Ushikoshi-Nakayama R, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S, Protein Sci. 2004 Nov;13(11):3038-42. Epub 2004 Sep 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15459330 15459330] | Crystal structures of possible lysine decarboxylases from Thermus thermophilus HB8., Kukimoto-Niino M, Murayama K, Kato-Murayama M, Idaka M, Bessho Y, Tatsuguchi A, Ushikoshi-Nakayama R, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S, Protein Sci. 2004 Nov;13(11):3038-42. Epub 2004 Sep 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15459330 15459330] | ||
| - | [[Category: Protein complex]] | ||
| - | [[Category: Thermus thermophilus]] | ||
[[Category: Idaka, M.]] | [[Category: Idaka, M.]] | ||
[[Category: Kukimoto-Niino, M.]] | [[Category: Kukimoto-Niino, M.]] | ||
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[[Category: Terada, T.]] | [[Category: Terada, T.]] | ||
[[Category: Yokoyama, S.]] | [[Category: Yokoyama, S.]] | ||
| - | [[Category: | + | [[Category: Riken structural genomics/proteomics initiative]] |
| - | [[Category: | + | [[Category: Rossman fold]] |
| - | [[Category: | + | [[Category: Rsgi]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:32:16 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 10:32, 3 May 2008
Crystal structure of the conserved hypothetical protein TT1887 from Thermus thermophilus HB8
Overview
TT1887 and TT1465 from Thermus thermophilus HB8 are conserved hypothetical proteins, and are annotated as possible lysine decarboxylases in the Pfam database. Here we report the crystal structures of TT1887 and TT1465 at 1.8 A and 2.2 A resolutions, respectively, as determined by the multiwavelength anomalous dispersion (MAD) method. TT1887 is a homotetramer, while TT1465 is a homohexamer in the crystal and in solution. The structures of the TT1887 and TT1465 monomers contain single domains with the Rossmann fold, comprising six alpha helices and seven beta strands, and are quite similar to each other. The major structural differences exist in the N terminus of TT1465, where there are two additional alpha helices. A comparison of the structures revealed the elements that are responsible for the different oligomerization modes. The distributions of the electrostatic potential on the solvent-accessible surfaces suggested putative active sites.
About this Structure
Full crystallographic information is available from OCA.
Reference
Crystal structures of possible lysine decarboxylases from Thermus thermophilus HB8., Kukimoto-Niino M, Murayama K, Kato-Murayama M, Idaka M, Bessho Y, Tatsuguchi A, Ushikoshi-Nakayama R, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S, Protein Sci. 2004 Nov;13(11):3038-42. Epub 2004 Sep 30. PMID:15459330 Page seeded by OCA on Sat May 3 13:32:16 2008
