9d1u
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Map of influenza hemagglutinin A/Sing/INFIMH/16 expressed in GntI- cells== | |
| - | + | <StructureSection load='9d1u' size='340' side='right'caption='[[9d1u]], [[Resolution|resolution]] 3.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9d1u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9D1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9D1U FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9d1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9d1u OCA], [https://pdbe.org/9d1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9d1u RCSB], [https://www.ebi.ac.uk/pdbsum/9d1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9d1u ProSAT]</span></td></tr> |
| - | [[Category: Torrents | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/A0A2R4U2X2_9INFA A0A2R4U2X2_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[ARBA:ARBA00059860][RuleBase:RU003324] |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Influenza A virus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Torrents de la Pena A]] | ||
| + | [[Category: Ward AB]] | ||
| + | [[Category: De Paiva Froes Rocha R]] | ||
Current revision
Map of influenza hemagglutinin A/Sing/INFIMH/16 expressed in GntI- cells
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