9lvk

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Current revision (08:22, 13 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9lvk is ON HOLD until Paper Publication
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==Cryo-EM structure of CASTOR1 bound human GATOR2 complex==
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<StructureSection load='9lvk' size='340' side='right'caption='[[9lvk]], [[Resolution|resolution]] 3.59&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9lvk]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LVK FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.59&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lvk OCA], [https://pdbe.org/9lvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lvk RCSB], [https://www.ebi.ac.uk/pdbsum/9lvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lvk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WDR59_HUMAN WDR59_HUMAN] As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027, PubMed:36577058). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:27487210).<ref>PMID:23723238</ref> <ref>PMID:25457612</ref> <ref>PMID:27487210</ref> <ref>PMID:35831510</ref> <ref>PMID:36528027</ref> <ref>PMID:36577058</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Su M-Y]]

Current revision

Cryo-EM structure of CASTOR1 bound human GATOR2 complex

PDB ID 9lvk

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