9rgb
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==M.tuberculosis MmpS5L5-acpM complex== | |
| - | + | <StructureSection load='9rgb' size='340' side='right'caption='[[9rgb]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9rgb]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria], [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] and [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RGB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HH:O-[(S)-HYDROXY{[(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL]OXY}PHOSPHORYL]-L-SERINE'>4HH</scene>, <scene name='pdbligand=L9Q:(1S)-2-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(OCTADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>L9Q</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rgb OCA], [https://pdbe.org/9rgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rgb RCSB], [https://www.ebi.ac.uk/pdbsum/9rgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rgb ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Luisi | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MMPS5_MYCTU MMPS5_MYCTU] Part of an export system, which is required for biosynthesis and secretion of siderophores. Essential for virulence.<ref>PMID:23431276</ref> Overexpression of the system confers non-target based resistance to azoles, clofazimine and bedaquiline, via an efflux mechanism.<ref>PMID:18851927</ref> <ref>PMID:25010492</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aequorea victoria]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Mycolicibacterium smegmatis MC2 155]] | ||
| + | [[Category: Fountain AJ]] | ||
| + | [[Category: Luisi BF]] | ||
| + | [[Category: Ramakrishnan L]] | ||
Current revision
M.tuberculosis MmpS5L5-acpM complex
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