9hix

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Current revision (06:15, 20 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9hix is ON HOLD until Paper Publication
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==Cryo-EM structure of CAK (CDK7 D97N mutant) in complex with THZ1==
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<StructureSection load='9hix' size='340' side='right'caption='[[9hix]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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Authors: Cushing, V.I., Greber, B.J., Ali, S., Lai, C.-F., Bevan, C.L., Coombes, R.C., Buluwela, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9hix]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HIX FirstGlance]. <br>
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Description: Cryo-EM structure of CAK (CDK7 D97N mutant) in complex with THZ1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=V0G:~{N}-[3-[[5-chloranyl-4-(1~{H}-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[4-(dimethylamino)butanoylamino]benzamide'>V0G</scene></td></tr>
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[[Category: Lai, C.-F]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hix OCA], [https://pdbe.org/9hix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hix RCSB], [https://www.ebi.ac.uk/pdbsum/9hix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hix ProSAT]</span></td></tr>
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[[Category: Bevan, C.L]]
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</table>
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[[Category: Cushing, V.I]]
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== Function ==
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[[Category: Coombes, R.C]]
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[https://www.uniprot.org/uniprot/MAT1_HUMAN MAT1_HUMAN] Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.<ref>PMID:10024882</ref>
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[[Category: Greber, B.J]]
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== References ==
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[[Category: Buluwela, L]]
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<references/>
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[[Category: Ali, S]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ali S]]
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[[Category: Bevan CL]]
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[[Category: Buluwela L]]
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[[Category: Coombes RC]]
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[[Category: Cushing VI]]
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[[Category: Greber BJ]]
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[[Category: Lai C-F]]

Current revision

Cryo-EM structure of CAK (CDK7 D97N mutant) in complex with THZ1

PDB ID 9hix

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