9hj0

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Current revision (06:15, 20 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9hj0 is ON HOLD until Paper Publication
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==Cryo-EM structure of CAK (CDK7 D97N mutant) in complex with Samuraciclib==
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<StructureSection load='9hj0' size='340' side='right'caption='[[9hj0]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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Authors: Cushing, V.I., Greber, B.J., Ali, S., Lai, C.-F., Bevan, C.L., Coombes, R.C., Buluwela, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9hj0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HJ0 FirstGlance]. <br>
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Description: Cryo-EM structure of CAK (CDK7 D97N mutant) in complex with Samuraciclib
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=I74:(3R,4R)-4-[[[7-[(PHENYLMETHYL)AMINO]-3-PROPAN-2-YL-PYRAZOLO[1,5-A]PYRIMIDIN-5-YL]AMINO]METHYL]PIPERIDIN-3-OL'>I74</scene></td></tr>
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[[Category: Greber, B.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hj0 OCA], [https://pdbe.org/9hj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hj0 RCSB], [https://www.ebi.ac.uk/pdbsum/9hj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hj0 ProSAT]</span></td></tr>
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[[Category: Coombes, R.C]]
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</table>
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[[Category: Ali, S]]
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== Function ==
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[[Category: Buluwela, L]]
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[https://www.uniprot.org/uniprot/MAT1_HUMAN MAT1_HUMAN] Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.<ref>PMID:10024882</ref>
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[[Category: Cushing, V.I]]
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== References ==
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[[Category: Lai, C.-F]]
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<references/>
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[[Category: Bevan, C.L]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ali S]]
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[[Category: Bevan CL]]
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[[Category: Buluwela L]]
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[[Category: Coombes RC]]
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[[Category: Cushing VI]]
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[[Category: Greber BJ]]
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[[Category: Lai C-F]]

Current revision

Cryo-EM structure of CAK (CDK7 D97N mutant) in complex with Samuraciclib

PDB ID 9hj0

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