9qm9

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Current revision (06:24, 20 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9qm9 is ON HOLD until 2027-03-22
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==TMEM55B tandem RING-like domains in complex with RILPL1 C-terminal peptide==
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<StructureSection load='9qm9' size='340' side='right'caption='[[9qm9]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9qm9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QM9 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qm9 OCA], [https://pdbe.org/9qm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qm9 RCSB], [https://www.ebi.ac.uk/pdbsum/9qm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qm9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PP4P1_HUMAN PP4P1_HUMAN] Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (PubMed:29146937). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (PubMed:25035345).<ref>PMID:16365287</ref> <ref>PMID:25035345</ref> <ref>PMID:29146937</ref> <ref>PMID:29644770</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Khan AR]]
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[[Category: Waschbuesch D]]

Current revision

TMEM55B tandem RING-like domains in complex with RILPL1 C-terminal peptide

PDB ID 9qm9

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OCA

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