9s44
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human Histone Deacetylase SIRT2== | |
| - | + | <StructureSection load='9s44' size='340' side='right'caption='[[9s44]], [[Resolution|resolution]] 2.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9s44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9S44 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9s44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s44 OCA], [https://pdbe.org/9s44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s44 RCSB], [https://www.ebi.ac.uk/pdbsum/9s44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s44 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Groll | + | [https://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Papenkordt | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Bracher F]] | ||
| + | [[Category: Frei M]] | ||
| + | [[Category: Friedrich F]] | ||
| + | [[Category: Groll M]] | ||
| + | [[Category: Heider A]] | ||
| + | [[Category: Huber EM]] | ||
| + | [[Category: Jung M]] | ||
| + | [[Category: Papenkordt N]] | ||
| + | [[Category: Wein T]] | ||
| + | [[Category: Wirawan R]] | ||
Current revision
Human Histone Deacetylase SIRT2
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Categories: Homo sapiens | Large Structures | Bracher F | Frei M | Friedrich F | Groll M | Heider A | Huber EM | Jung M | Papenkordt N | Wein T | Wirawan R
