9ven

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Current revision (06:25, 20 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9ven is ON HOLD until Paper Publication
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==structure of human KCNQ1-CaM-PIP2 complex with bent conformation==
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<StructureSection load='9ven' size='340' side='right'caption='[[9ven]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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Authors: Cui, C., Kermani, A., Cui, J., Sun, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ven]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VEN FirstGlance]. <br>
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Description: structure of human KCNQ1-CaM-PIP2 complex with bent conformation
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PT5:(1S)-2-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}-1-[(OCTADECANOYLOXY)METHYL]ETHYL+(8E,11E)-ICOSA-5,8,11,14-TETRAENOATE'>PT5</scene></td></tr>
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[[Category: Kermani, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ven FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ven OCA], [https://pdbe.org/9ven PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ven RCSB], [https://www.ebi.ac.uk/pdbsum/9ven PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ven ProSAT]</span></td></tr>
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[[Category: Cui, C]]
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</table>
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[[Category: Cui, J]]
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== Disease ==
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[[Category: Sun, J]]
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cui C]]
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[[Category: Cui J]]
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[[Category: Kermani A]]
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[[Category: Sun J]]

Current revision

structure of human KCNQ1-CaM-PIP2 complex with bent conformation

PDB ID 9ven

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