9gs5

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Current revision (06:33, 20 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9gs5 is ON HOLD until Paper Publication
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==Cryo-EM structure of human SLC35B1-E33A variant with ADP in outward facing conformation==
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<StructureSection load='9gs5' size='340' side='right'caption='[[9gs5]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9gs5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GS5 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gs5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gs5 OCA], [https://pdbe.org/9gs5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gs5 RCSB], [https://www.ebi.ac.uk/pdbsum/9gs5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gs5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S35B1_HUMAN S35B1_HUMAN] ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction (PubMed:30154480, PubMed:35041824). Regulates ER energy metabolism and protein biogenesis. Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply. Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER (PubMed:30154480, PubMed:35041824). Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established (PubMed:30154480, PubMed:35041824).<ref>PMID:30154480</ref> <ref>PMID:35041824</ref> ATP:ADP antiporter.<ref>PMID:30154480</ref> <ref>PMID:35041824</ref> ATP:ADP antiporter.<ref>PMID:30154480</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Ahn D]]
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[[Category: Drew D]]
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[[Category: Gulati A]]
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[[Category: Suades A]]

Current revision

Cryo-EM structure of human SLC35B1-E33A variant with ADP in outward facing conformation

PDB ID 9gs5

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OCA

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