High affinity nerve growth factor receptor

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*High affinity nerve growth factor receptor; Domains – nerve growth factor-binding 36-383; transmembrane 410-447; catalytic+juxtamembrane 376-698; kinase 498-796
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*High affinity nerve growth factor receptor; Domains – nerve growth factor-binding 36-383; D5 – 281-382; transmembrane 410-447; catalytic+juxtamembrane 376-698; kinase 498-796
**[[1he7]] – hTrkA residues 282-413 – human<br />
**[[1he7]] – hTrkA residues 282-413 – human<br />
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**[[4crp]] – hTrkA nerve growth factor-binding domain (mutant) – NMR<br />
**[[4crp]] – hTrkA nerve growth factor-binding domain (mutant) – NMR<br />
**[[4f0i]], [[4gt5]] – hTrkA kinase domain <br />
**[[4f0i]], [[4gt5]] – hTrkA kinase domain <br />
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*High affinity nerve growth factor receptor complex
 
**[[5kvt]], [[5wr7]] – hTrkA kinase domain + anticancer drug<br />
**[[5kvt]], [[5wr7]] – hTrkA kinase domain + anticancer drug<br />
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**[[4aoj]], [[4pmm]], [[4pmp]], [[4pms]], [[4pmt]], [[4yne]], [[4yps]], [[5h3q]], [[6dkb]], [[6dkg]], [[6dki]], [[6dkw]], [[6j5l]], [[6npt]], [[6nsp]], [[6nss]], [[6iqn]], [[6pl1]], [[6pl2]], [[6pl3]], [[6pl4]], [[7xaf]], [[7xbi]] - hTrkA kinase domain + inhibitor<br />
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**[[4aoj]], [[4pmm]], [[4pmp]], [[4pms]], [[4pmt]], [[4yne]], [[4yps]], [[5h3q]], [[6dkb]], [[6dkg]], [[6dki]], [[6dkw]], [[6iqn]], [[6j5l]], [[6npt]], [[6nsp]], [[6nss]], [[6pl1]], [[6pl2]], [[6pl3]], [[6pl4]], [[7xaf]], [[7xbi]], [[8j61]], [[8j63]] – hTrkA kinase domain + inhibitor<br />
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**[[5kmj]], [[5kmk]], [[5kml]], [[5kmm]], [[5kmn]], [[5kmo]], [[6d1y]], [[6d1z]], [[6d20]], [[5i8a]], [[5jfs]], [[5jfv]], [[5jfw]], [[5jfx]], [[5kmi]], [[6pma]], [[6pmb]], [[6pmc]], [[6pme]] – hTrkA catalytic+juxtamembrane domains 376-698 + inhibitor <br />
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**[[8j5w]], [[8j5x]] – hTrkA kinase domain (mutant) + inhibitor<br />
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**[[5i8a]], [[5jfs]], [[5jfv]], [[5jfw]], [[5jfx]], [[5kmj]], [[5kmk]], [[5kml]], [[5kmm]], [[5kmn]], [[5kmo]], [[6d1y]], [[6d1z]], [[6d20]], [[6pma]], [[6pmb]], [[6pmc]], [[6pme]] – hTrkA catalytic+juxtamembrane domains + inhibitor <br />
**[[2ifg]] – hTrkA nerve growth factor-binding domain + nerve growth factor <br />
**[[2ifg]] – hTrkA nerve growth factor-binding domain + nerve growth factor <br />
**[[7n3t]] – hTrkA nerve growth factor-binding domain + TrkA-binding miniprotein<br />
**[[7n3t]] – hTrkA nerve growth factor-binding domain + TrkA-binding miniprotein<br />
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**[[8ytd]], [[8yte]] – hTrkA D5 domain + cyclic peptide<br />
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}}
}}

Revision as of 06:59, 26 August 2025

Glycosylated human TrkA (cyan and green) complex with nerve growth factor (yellow and magenta) (PDB code 2ifg)

Drag the structure with the mouse to rotate

3D structures of high affinity nerve growth factor receptor

Updated on 26-August-2025

References

  1. ↑ 1.0 1.1 Gill JS, Windebank AJ. Direct activation of the high-affinity nerve growth factor receptor by a non-peptide symmetrical polyanion. Neuroscience. 1998 Dec;87(4):855-60. PMID:9759973
  2. ↑ Zhang Q, Descamps O, Hart MJ, Poksay KS, Spilman P, Kane DJ, Gorostiza O, John V, Bredesen DE. Paradoxical effect of TrkA inhibition in Alzheimer's disease models. J Alzheimers Dis. 2014;40(3):605-617. doi: 10.3233/JAD-130017. PMID:24531152 doi:http://dx.doi.org/10.3233/JAD-130017
  3. ↑ Hirose M, Kuroda Y, Murata E. NGF/TrkA Signaling as a Therapeutic Target for Pain. Pain Pract. 2016 Feb;16(2):175-82. doi: 10.1111/papr.12342. Epub 2015 Aug 27. PMID:26452158 doi:http://dx.doi.org/10.1111/papr.12342
  4. ↑ Wehrman T, He X, Raab B, Dukipatti A, Blau H, Garcia KC. Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Neuron. 2007 Jan 4;53(1):25-38. PMID:17196528 doi:10.1016/j.neuron.2006.09.034
  5. ↑ Wiesmann C, Ultsch MH, Bass SH, de Vos AM. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 1999 Sep 9;401(6749):184-8. PMID:10490030 doi:10.1038/43705

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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