8ulz

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Current revision (07:00, 27 August 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ulz is ON HOLD until Paper Publication
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==LSD1-CoREST in complex with T18 and SNAG peptide==
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<StructureSection load='8ulz' size='340' side='right'caption='[[8ulz]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
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Authors: Caroli, J., Mattevi, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ulz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ULZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ULZ FirstGlance]. <br>
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Description: LSD1-CoREST in complex with T18 and SNAG peptide
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.32&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YAO:[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl+(2R,3S,4S)-5-[(1R,3S,3aS,13R)-3-(3-benzamidophenyl)-1-hydroxy-10,11-dimethyl-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl+dihydrogen+diphosphate+(non-preferred+name)'>YAO</scene></td></tr>
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[[Category: Mattevi, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ulz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ulz OCA], [https://pdbe.org/8ulz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ulz RCSB], [https://www.ebi.ac.uk/pdbsum/8ulz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ulz ProSAT]</span></td></tr>
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[[Category: Caroli, J]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SNAI1_HUMAN SNAI1_HUMAN] Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.<ref>PMID:10655587</ref> <ref>PMID:16096638</ref> <ref>PMID:15647282</ref> <ref>PMID:20121949</ref> <ref>PMID:20562920</ref> <ref>PMID:21952048</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Caroli J]]
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[[Category: Mattevi A]]

Current revision

LSD1-CoREST in complex with T18 and SNAG peptide

PDB ID 8ulz

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