8w1a
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM Structure of KSHV ORF74 Apo Dimer at 2.8A== | |
| - | + | <StructureSection load='8w1a' size='340' side='right'caption='[[8w1a]], [[Resolution|resolution]] 2.89Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8w1a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W1A FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.89Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w1a OCA], [https://pdbe.org/8w1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w1a RCSB], [https://www.ebi.ac.uk/pdbsum/8w1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w1a ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VGPCR_HHV8P VGPCR_HHV8P] Receptor that signals constitutively via several signaling pathways including PI3K/AKT as well as mitogen- and stress-activated/MAP kinases. Promotes host cell proliferation and survival, modulates cell migration, stimulates angiogenesis, and recruits inflammatory cells, both in expressing cells and in neighboring cells. Maintains chronic activation of NF-kappa-B via interaction with host CADM1 (PubMed:29698475).<ref>PMID:12477810</ref> <ref>PMID:14724579</ref> <ref>PMID:29698475</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human gammaherpesvirus 8]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dai X]] | ||
| + | [[Category: Jung J]] | ||
| + | [[Category: Sahoo B]] | ||
| + | [[Category: Seo HD]] | ||
Current revision
Cryo-EM Structure of KSHV ORF74 Apo Dimer at 2.8A
| |||||||||||
