9ggg
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Thromboxane A2 receptor-miniGq Protein Complex bound to I-BOP== | |
| - | + | <StructureSection load='9ggg' size='340' side='right'caption='[[9ggg]], [[Resolution|resolution]] 3.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9ggg]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GGG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.25Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IK0:(~{Z})-7-[(1~{S},2~{R},3~{R},4~{R})-3-[(~{E},3~{R})-4-(4-iodanylphenoxy)-3-oxidanyl-but-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic+acid'>A1IK0</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ggg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ggg OCA], [https://pdbe.org/9ggg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ggg RCSB], [https://www.ebi.ac.uk/pdbsum/9ggg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ggg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TA2R_HUMAN TA2R_HUMAN] Bleeding diathesis due to thromboxane synthesis deficiency. Disease susceptibility is associated with variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TA2R_HUMAN TA2R_HUMAN] Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.<ref>PMID:8613548</ref> Activates adenylyl cyclase.<ref>PMID:8613548</ref> Inhibits adenylyl cyclase.<ref>PMID:8613548</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Caffrey M]] | ||
| + | [[Category: Krawinski P]] | ||
| + | [[Category: Matzov D]] | ||
| + | [[Category: Shalev Benami M]] | ||
Current revision
Cryo-EM structure of Thromboxane A2 receptor-miniGq Protein Complex bound to I-BOP
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