9hms

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Current revision (10:26, 3 September 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9hms is ON HOLD until Paper Publication
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==Cryo-EM structure of human separase bound to SCC1 (310-550 aa) and SA2==
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<StructureSection load='9hms' size='340' side='right'caption='[[9hms]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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Authors: Yu, J., Schmidt, S., Botto, M., Boland, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9hms]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HMS FirstGlance]. <br>
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Description: Cryo-EM structure of human separase bound to SCC1 (310-550 aa) and SA2
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Botto, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hms OCA], [https://pdbe.org/9hms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hms RCSB], [https://www.ebi.ac.uk/pdbsum/9hms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hms ProSAT]</span></td></tr>
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[[Category: Schmidt, S]]
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</table>
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[[Category: Boland, A]]
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== Function ==
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[[Category: Yu, J]]
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[https://www.uniprot.org/uniprot/STAG2_HUMAN STAG2_HUMAN] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.<ref>PMID:12034751</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Boland A]]
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[[Category: Botto M]]
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[[Category: Schmidt S]]
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[[Category: Yu J]]

Current revision

Cryo-EM structure of human separase bound to SCC1 (310-550 aa) and SA2

PDB ID 9hms

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