1wjf

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[[Image:1wjf.gif|left|200px]]
[[Image:1wjf.gif|left|200px]]
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{{Structure
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|PDB= 1wjf |SIZE=350|CAPTION= <scene name='initialview01'>1wjf</scene>
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The line below this paragraph, containing "STRUCTURE_1wjf", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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{{STRUCTURE_1wjf| PDB=1wjf | SCENE= }}
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|RELATEDENTRY=[[1wje|1WJE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wjf OCA], [http://www.ebi.ac.uk/pdbsum/1wjf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wjf RCSB]</span>
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'''SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, 40 STRUCTURES'''
'''SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, 40 STRUCTURES'''
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[[Category: Clore, G M.]]
[[Category: Clore, G M.]]
[[Category: Gronenborn, A M.]]
[[Category: Gronenborn, A M.]]
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[[Category: aid]]
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[[Category: Aid]]
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[[Category: aspartyl protease]]
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[[Category: Aspartyl protease]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: polyprotein]]
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[[Category: Polyprotein]]
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[[Category: zn-binding protein]]
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[[Category: Zn-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:45:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:37:06 2008''
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Revision as of 10:45, 3 May 2008

Image:1wjf.gif

Template:STRUCTURE 1wjf

SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, 40 STRUCTURES


Overview

The solution structure of His12 --> Cys mutant of the N-terminal zinc binding domain (residues 1-55; IN(1-55)) of HIV-1 integrase complexed to cadmium has been solved by multidimensional heteronuclear NMR spectroscopy. The overall structure is very similar to that of the wild-type N-terminal domain complexed to zinc. In contrast to the wild-type domain, however, which exists in two interconverting conformational states arising from different modes of coordination of the two histidine side chains to the metal, the cadmium complex of the His12 --> Cys mutant exists in only a single form at low pH. The conformation of the polypeptide chain encompassing residues 10-18 is intermediate between the two forms of the wild-type complex.

About this Structure

1WJF is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Solution structure of the His12 --> Cys mutant of the N-terminal zinc binding domain of HIV-1 integrase complexed to cadmium., Cai M, Huang Y, Caffrey M, Zheng R, Craigie R, Clore GM, Gronenborn AM, Protein Sci. 1998 Dec;7(12):2669-74. PMID:9865962 Page seeded by OCA on Sat May 3 13:45:43 2008

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