Histone acetyltransferase 3D structures
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *Histone acetyltransferase; Human domains – WH 100-182; DPF 194-323; HAT 170-458; catalytic 497-662; bromodomain 729-837; | + | *Histone acetyltransferase; Human domains – WH 100-182; DPF 194-323; HAT 170-458; catalytic 497-662; bromodomain 729-837; acetyltransferase 1086-1566 |
**[[1f68]] – hHAT bromodomain (mutant) – human – NMR | **[[1f68]] – hHAT bromodomain (mutant) – human – NMR | ||
| Line 31: | Line 31: | ||
**[[5j8c]], [[5j8f]] - hHAT KAT8 HAT domain (mutant)<br /> | **[[5j8c]], [[5j8f]] - hHAT KAT8 HAT domain (mutant)<br /> | ||
**[[7by1]] - mHAT KAT2A N-terminal 67-378 - mouse<br /> | **[[7by1]] - mHAT KAT2A N-terminal 67-378 - mouse<br /> | ||
| + | **[[8xuw]] - HAT GCN bromodomain - fungus<br /> | ||
**[[1qso]] - yHAT HPA2 – yeast<br /> | **[[1qso]] - yHAT HPA2 – yeast<br /> | ||
**[[3to7]] – yHAT Esa1<br /> | **[[3to7]] – yHAT Esa1<br /> | ||
| Line 40: | Line 41: | ||
**[[6ia8]], [[6iad]], [[6iaz]] - HAT – ''Methanocaldococcus infernus''<br /> | **[[6ia8]], [[6iad]], [[6iaz]] - HAT – ''Methanocaldococcus infernus''<br /> | ||
**[[6if4]] - HAT – ''Trypanosoma brucei''<br /> | **[[6if4]] - HAT – ''Trypanosoma brucei''<br /> | ||
| - | **[[7bwz]], [[7bx0]], [[7bx1]], [[7bxw]], [[7c3o]] - | + | **[[7bwz]], [[7bx0]], [[7bx1]], [[7bxw]], [[7c3o]] - CaHAT RTT109 – ''Candida albicans''<br /> |
| + | **[[8gq3]], [[8gq4]] - CaHAT RTT109 (mutant)<br /> | ||
*Histone acetyltransferase binary complexes | *Histone acetyltransferase binary complexes | ||
| Line 51: | Line 53: | ||
**[[2p0w]] - hHAT 1 catalytic domain + histone H4 peptide | **[[2p0w]] - hHAT 1 catalytic domain + histone H4 peptide | ||
| - | + | **[[9mjg]] – hHAT1 B catalytic subunit + inhibitor<br /> | |
**[[2rnw]], [[2rnx]] - hHAT PCAF bromodomain + histone H3 peptide - NMR<br /> | **[[2rnw]], [[2rnx]] - hHAT PCAF bromodomain + histone H3 peptide - NMR<br /> | ||
| - | **[[5h84]] - hHAT KAT2A catalytic domain + propionyl CoA<br /> | + | **[[5h84]], [[8h65]], [[8h66]] - hHAT KAT2A catalytic domain + propionyl CoA<br /> |
**[[5h86]] - hHAT KAT2A catalytic domain + butyryl CoA<br /> | **[[5h86]] - hHAT KAT2A catalytic domain + butyryl CoA<br /> | ||
**[[5trl]] - hHAT KAT2A catalytic domain + succinyl CoA<br /> | **[[5trl]] - hHAT KAT2A catalytic domain + succinyl CoA<br /> | ||
| + | **[[8e6o]] - hHAT KAT2A catalytic domain + lactyl CoA<br /> | ||
| + | **[[8h6c]] - hHAT KAT2A catalytic domain + malonyl CoA<br /> | ||
**[[5mlj]], [[6j3p]] - hHAT KAT2A bromodomain + inhibitor<br /> | **[[5mlj]], [[6j3p]] - hHAT KAT2A bromodomain + inhibitor<br /> | ||
| - | ** | + | **[[5fdz]], [[5fe0]], [[5fe1]], [[5fe2]], [[5fe3]], [[5fe4]], [[5fe5]], [[5fe6]], [[5fe7]], [[5fe8]], [[5fe9]], [[5lvq]], [[5lvr]], [[5mkx]], [[6j3o]], [[9jut]] - hHAT KAT2B bromodomain + inhibitor<br /> |
**[[4dnc]] – hHAT KAT8 HAT domain + male-specific lethal 1 homolog<br /> | **[[4dnc]] – hHAT KAT8 HAT domain + male-specific lethal 1 homolog<br /> | ||
**[[3v43]], [[4lk9]], [[4lka]], [[4llb]], [[5b75]], [[5b76]], [[5b77]], [[5b78]], [[6lsb]] - hHAT KAT6A + H3.1 peptide<br /> | **[[3v43]], [[4lk9]], [[4lka]], [[4llb]], [[5b75]], [[5b76]], [[5b77]], [[5b78]], [[6lsb]] - hHAT KAT6A + H3.1 peptide<br /> | ||
**[[7y43]], [[8h7a]] - hHAT KAT6A + DNA<br /> | **[[7y43]], [[8h7a]] - hHAT KAT6A + DNA<br /> | ||
| + | **[[8dd5]], [[9fkr]] - hHAT KAT6A + inhibitor<br /> | ||
**[[5u2j]], [[6oie]] - hHAT KAT6B + H3K14BU peptide<br /> | **[[5u2j]], [[6oie]] - hHAT KAT6B + H3K14BU peptide<br /> | ||
**[[5gk9]], [[6maj]], [[6mak]], [[7d0o]] - hHAT KAT7 + BRD1<br /> | **[[5gk9]], [[6maj]], [[6mak]], [[7d0o]] - hHAT KAT7 + BRD1<br /> | ||
**[[4dnc]] – hHAT KAT8 HAT domain + male-specific lethal 1 homolog<br /> | **[[4dnc]] – hHAT KAT8 HAT domain + male-specific lethal 1 homolog<br /> | ||
**[[6ct2]], [[6ba2]] – hHAT KAT8 HAT domain + inhibitor<br /> | **[[6ct2]], [[6ba2]] – hHAT KAT8 HAT domain + inhibitor<br /> | ||
| - | **[[6oin]], [[6oio]], [[6oip]], [[6oir]], [[6owh]], [[6owi]], [[6pd8]], [[6pd9]], [[6pda]], [[6pdb]], [[6pdc]], [[6pdd]], [[6pde]], [[6pdf]], [[6pdg]] – hHAT KAT8 HAT domain (mutant) + inhibitor<br /> | + | **[[6oin]], [[6oio]], [[6oip]], [[6oir]], [[6owh]], [[6owi]], [[6pd8]], [[6pd9]], [[6pda]], [[6pdb]], [[6pdc]], [[6pdd]], [[6pde]], [[6pdf]], [[6pdg]], [[8w13]] – hHAT KAT8 HAT domain (mutant) + inhibitor<br /> |
**[[5h86]], [[6ba4]] - hHAT KAT8 HAT domain + acetyl CoA<br /> | **[[5h86]], [[6ba4]] - hHAT KAT8 HAT domain + acetyl CoA<br /> | ||
| - | **[[7kpy]] - hHAT 617-732 + inhibitor <br /> | + | **[[7kpy]], [[8fvs]] - hHAT 617-732 + inhibitor <br /> |
**[[7qgs]] - hHAT 330-440 + MRG-1<br /> | **[[7qgs]] - hHAT 330-440 + MRG-1<br /> | ||
| - | **[[5ml0]] - mHAT KAT2B bromodomain + inhibitor<br /> | + | **[[5ml0]] - mHAT KAT2B bromodomain + inhibitor <br /> |
| + | **[[8og2]] - mHAT acetyltransferase domain + acetyl-CoA | ||
| + | **[[8cn0]], [[8cna]], [[8cnb]] - mHAT acetyltransferase domain (mutant) + acetyl-CoA | ||
**[[1bob]] – yHAT 1 + acetyl-CoA | **[[1bob]] – yHAT 1 + acetyl-CoA | ||
| Line 90: | Line 97: | ||
**[[5tpx]] - HAT GCN5 + probe – ''Plasmodium falciparum''<br /> | **[[5tpx]] - HAT GCN5 + probe – ''Plasmodium falciparum''<br /> | ||
| - | *Histone acetyltransferase | + | *Histone acetyltransferase larger complexes |
**[[6vo5]] – hHAT B catalytic subunit + histone H4 + CoA derivative<br /> | **[[6vo5]] – hHAT B catalytic subunit + histone H4 + CoA derivative<br /> | ||
| + | **[[9dzn]] - hHAT KAT6A 501-784 + carboxymethyl CoA + histone H3K14<br /> | ||
**[[7d0p]], [[7d0q]], [[7d0r]], [[7d0s]] - hHAT KAT7 + BRD1 + CoA derivative<br /> | **[[7d0p]], [[7d0q]], [[7d0r]], [[7d0s]] - hHAT KAT7 + BRD1 + CoA derivative<br /> | ||
| + | **[[9mza]] – hHAT + BCL6 + TCIP3<br /> | ||
**[[3q33]] – yHAT RTT109 + vacuolar protein sorting-associated protein 75 + histone H3 peptide<br /> | **[[3q33]] – yHAT RTT109 + vacuolar protein sorting-associated protein 75 + histone H3 peptide<br /> | ||
**[[7xay]] – yHAT1 + HAT2 + ASF1 + histone H3 + histone H4 <br /> | **[[7xay]] – yHAT1 + HAT2 + ASF1 + histone H3 + histone H4 <br /> | ||
| Line 99: | Line 108: | ||
**[[4psx]] - yHAT B + H3 peptide + H4 peptide<br /> | **[[4psx]] - yHAT B + H3 peptide + H4 peptide<br /> | ||
**[[5j9q]], [[5j9t]], [[5j9u]], [[5j9w]] - yHAT Esa1 (mutant) + chromatin modification-related protein + enhancer of polycomb-like protein<br /> | **[[5j9q]], [[5j9t]], [[5j9u]], [[5j9w]] - yHAT Esa1 (mutant) + chromatin modification-related protein + enhancer of polycomb-like protein<br /> | ||
| - | **[[ | + | **[[7vvu]], [[7vvz]] - yHAT Esa1 + nucleosome – Cryo EM<br /> |
| + | **[[8x2x]], [[8x2y]], [[8x2z]], [[8x30]], [[8x31]], [[8x32]] - yHAT + nucleosome + chromatin modification-related protein + EAF6 – Cryo EM<br /> | ||
| + | **[[6cw2]], [[6cw3]] - yHAT GCN5 residues 67-316 + transcriptional adaptor + antibody<br /> | ||
**[[1q2c]] - TtHAT Gcn5 + CoA + histone H4 peptide | **[[1q2c]] - TtHAT Gcn5 + CoA + histone H4 peptide | ||
**[[1q2d]] - TtHAT Gcn5 + CoA + p53 peptide | **[[1q2d]] - TtHAT Gcn5 + CoA + p53 peptide | ||
| - | * Histone acetyltransferase P300; domains – core domain residues 1043-1519; bromodomain residues 1040-1161; acetyltransferase domain residues 1287-1664; TAZ2 domain 1723-1836: | + | * Histone acetyltransferase P300; domains – KIX 566-652; core domain residues 1043-1519; bromodomain residues 1040-1161; acetyltransferase domain residues 1287-1664; TAZ2 domain 1723-1836: |
| + | **[[9jej]] - hHAT P300 KIX domain (mutant)<br /> | ||
**[[3i3j]] – hHAT P300 bromodomain <br /> | **[[3i3j]] – hHAT P300 bromodomain <br /> | ||
**[[7uge]], [[7ugi]], [[7ugl]] - hHAT P300 bromodomain + inhibitor <br /> | **[[7uge]], [[7ugi]], [[7ugl]] - hHAT P300 bromodomain + inhibitor <br /> | ||
| Line 111: | Line 123: | ||
**[[6fgn]], [[6fgs]] - hHAT TAZ2 domain - NMR<br /> | **[[6fgn]], [[6fgs]] - hHAT TAZ2 domain - NMR<br /> | ||
**[[2mzd]] - hHAT TAZ2 domain (mutant) + p53 peptide - NMR<br /> | **[[2mzd]] - hHAT TAZ2 domain (mutant) + p53 peptide - NMR<br /> | ||
| + | **[[8e1d]] - hHAT TAZ2 domain (mutant) + microphthalmia-associated transcription factor - NMR<br /> | ||
**[[4bhw]] - hHAT P300 core (mutant)<br /> | **[[4bhw]] - hHAT P300 core (mutant)<br /> | ||
**[[6k4n]] - hHAT P300 bromodomain+acetyltransferase domains – Cryo EM<br /> | **[[6k4n]] - hHAT P300 bromodomain+acetyltransferase domains – Cryo EM<br /> | ||
| Line 127: | Line 140: | ||
**[[6gyr]] - hHAT P300 core+acetyltransferase domains + lysine CoA derivative<br /> | **[[6gyr]] - hHAT P300 core+acetyltransferase domains + lysine CoA derivative<br /> | ||
**[[5xzc]] - hHAT P300 core+acetyltransferase domains + p53<br /> | **[[5xzc]] - hHAT P300 core+acetyltransferase domains + p53<br /> | ||
| - | **[[5bt3]], [[ | + | **[[5bt3]], [[5lpk]], [[5lpm]], [[5nu5]], [[8fvf]] - hHAT P300 bromodomain + inhibitor<br /> |
| + | **[[9it5]] - hHAT P300 KAT domain + inhibitor<br /> | ||
**[[6gyt]] - hHAT P300 bromodomain + histone H4 peptide<br /> | **[[6gyt]] - hHAT P300 bromodomain + histone H4 peptide<br /> | ||
**[[7w9v]], [[8hag]], [[8hah]], [[8hai]], [[8haj]], [[8hak]] - hHAT P300 1098-1836 + nucleosome – Cryo EM<br /> | **[[7w9v]], [[8hag]], [[8hah]], [[8hai]], [[8haj]], [[8hak]] - hHAT P300 1098-1836 + nucleosome – Cryo EM<br /> | ||
Current revision
3D Structures of histone acetyltransferase
Updated on 08-September-2025
