1wks

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[[Image:1wks.gif|left|200px]]
[[Image:1wks.gif|left|200px]]
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{{Structure
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|PDB= 1wks |SIZE=350|CAPTION= <scene name='initialview01'>1wks</scene>
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The line below this paragraph, containing "STRUCTURE_1wks", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1wks| PDB=1wks | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wks OCA], [http://www.ebi.ac.uk/pdbsum/1wks PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wks RCSB]</span>
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'''Solution structure of an RNA stem-loop derived from the 3' conserved region of eel LINE UnaL2'''
'''Solution structure of an RNA stem-loop derived from the 3' conserved region of eel LINE UnaL2'''
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==About this Structure==
==About this Structure==
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1WKS is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKS OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKS OCA].
==Reference==
==Reference==
Solution structure of an RNA stem-loop derived from the 3' conserved region of eel LINE UnaL2., Baba S, Kajikawa M, Okada N, Kawai G, RNA. 2004 Sep;10(9):1380-7. Epub 2004 Jul 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15273327 15273327]
Solution structure of an RNA stem-loop derived from the 3' conserved region of eel LINE UnaL2., Baba S, Kajikawa M, Okada N, Kawai G, RNA. 2004 Sep;10(9):1380-7. Epub 2004 Jul 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15273327 15273327]
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[[Category: Protein complex]]
 
[[Category: Baba, S.]]
[[Category: Baba, S.]]
[[Category: Kajikawa, M.]]
[[Category: Kajikawa, M.]]
[[Category: Kawai, G.]]
[[Category: Kawai, G.]]
[[Category: Okada, N.]]
[[Category: Okada, N.]]
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[[Category: line]]
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[[Category: Line]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: pentaloop]]
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[[Category: Pentaloop]]
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[[Category: retrotransposition]]
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[[Category: Retrotransposition]]
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[[Category: rna]]
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[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:49:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:37:35 2008''
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Revision as of 10:49, 3 May 2008

Image:1wks.gif

Template:STRUCTURE 1wks

Solution structure of an RNA stem-loop derived from the 3' conserved region of eel LINE UnaL2


Overview

The eel long interspersed element (LINE) UnaL2 and its partner short interspersed element (SINE) share a conserved 3' tail containing a stem-loop that is critical for their retrotransposition. Presumably, the first step of retrotransposition is the recognition of their 3' tails by UnaL2-encoded reverse transcriptase. The solution structure of a 17-nucleotide RNA derived from the 3' tail of UnaL2 was determined by NMR. The GGAUA loop forms a specific structure in which the uridine is exposed to solvent with the third and fifth adenosines stacked. A sharp turn in the phosphodiester backbone occurs between the second guanosine and third adenosine. When the uridine is mutated (but not deleted), all mutants form the loop structure, indicating that the loop structure requires an exposed fourth residue. The retrotransposition assay in HeLa cells revealed that retrotransposition requires the second guanosine, although any nucleoside functions at the fourth position, suggesting that UnaL2 reverse transcriptase specifically recognizes the 5' side of the GGANA loop.

About this Structure

Full crystallographic information is available from OCA.

Reference

Solution structure of an RNA stem-loop derived from the 3' conserved region of eel LINE UnaL2., Baba S, Kajikawa M, Okada N, Kawai G, RNA. 2004 Sep;10(9):1380-7. Epub 2004 Jul 23. PMID:15273327 Page seeded by OCA on Sat May 3 13:49:03 2008

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