9kcc
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==DNA duplex containing copper-mediated 5-fluorouracil-cytosine base pairs== | |
| + | <StructureSection load='9kcc' size='340' side='right'caption='[[9kcc]], [[Resolution|resolution]] 2.31Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[9kcc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KCC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=UFP:5-FLUORO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>UFP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kcc OCA], [https://pdbe.org/9kcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kcc RCSB], [https://www.ebi.ac.uk/pdbsum/9kcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kcc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Only mercury(II) and silver(I) ions are known to specifically bind to natural and naturally modified base pairs in duplex DNA to form metal-mediated base pairs. We found novel, specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil (FdU) in duplex DNA, forming C-Cu-FdU and FdU-Cu-C base pairs. | ||
| - | + | Novel specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil in duplex DNA.,Torigoe H, Hirabayashi K, Adachi S, Kondo J Dalton Trans. 2025 May 6;54(18):7208-7213. doi: 10.1039/d5dt00619h. PMID:40265694<ref>PMID:40265694</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Adachi | + | <div class="pdbe-citations 9kcc" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: Kondo | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Adachi S]] | ||
| + | [[Category: Hirabayashi K]] | ||
| + | [[Category: Kondo J]] | ||
| + | [[Category: Torigoe H]] | ||
Current revision
DNA duplex containing copper-mediated 5-fluorouracil-cytosine base pairs
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