9ntc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Synaptic Vesicle Protein 2A Bound to Brivaracetam and UCB1244283== | |
| - | + | <StructureSection load='9ntc' size='340' side='right'caption='[[9ntc]], [[Resolution|resolution]] 3.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9ntc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NTC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.05Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B1I:(3~{S})-4-(3,5-dimethylphenyl)-~{N}-(2-methoxyphenyl)-3-methyl-butanamide'>A1B1I</scene>, <scene name='pdbligand=A1B1J:(3~{R})-4-(3,5-dimethylphenyl)-~{N}-(2-methoxyphenyl)-3-methyl-butanamide'>A1B1J</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=VLX:(2~{S})-2-[(4~{R})-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide'>VLX</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ntc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ntc OCA], [https://pdbe.org/9ntc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ntc RCSB], [https://www.ebi.ac.uk/pdbsum/9ntc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ntc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SV2A_HUMAN SV2A_HUMAN] Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Coleman JA]] | ||
| + | [[Category: Horanyi PS]] | ||
| + | [[Category: Ledecq M]] | ||
| + | [[Category: Martin MF]] | ||
| + | [[Category: Mittal A]] | ||
Revision as of 04:15, 14 September 2025
Structure of Synaptic Vesicle Protein 2A Bound to Brivaracetam and UCB1244283
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