9sa1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "9sa1" [edit=sysop:move=sysop])
Current revision (04:20, 14 September 2025) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 9sa1 is ON HOLD
+
==The RING domain of IDOL==
-
 
+
<StructureSection load='9sa1' size='340' side='right'caption='[[9sa1]], [[Resolution|resolution]] 1.06&Aring;' scene=''>
-
Authors: Bradshaw, W.J., He, L., Guenther, F., Murphy, E.J.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[9sa1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SA1 FirstGlance]. <br>
-
Description: The RING domain of IDOL
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.056&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: He, L]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sa1 OCA], [https://pdbe.org/9sa1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sa1 RCSB], [https://www.ebi.ac.uk/pdbsum/9sa1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sa1 ProSAT]</span></td></tr>
-
[[Category: Bradshaw, W.J]]
+
</table>
-
[[Category: Guenther, F]]
+
== Function ==
-
[[Category: Murphy, E.J]]
+
[https://www.uniprot.org/uniprot/MYLIP_HUMAN MYLIP_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.<ref>PMID:10593918</ref> <ref>PMID:14550572</ref> <ref>PMID:12826659</ref> <ref>PMID:19520913</ref> <ref>PMID:20427281</ref> <ref>PMID:22109552</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Bradshaw WJ]]
 +
[[Category: Guenther F]]
 +
[[Category: He L]]
 +
[[Category: Murphy EJ]]

Current revision

The RING domain of IDOL

PDB ID 9sa1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/9sa1"
Personal tools